未足月胎膜早破（PPROM）与羊水中病毒基因组的存在无关。
Preterm prelabor rupture of membranes (PPROM) is not associated with presence of viral genomes in the amniotic fluid.
机构信息
Enterovirus Laboratory, Medical Faculty, Slovak Medical University, Limbova 12, 83303 Bratislava, Slovak Republic.
出版信息
J Clin Virol. 2013 Nov;58(3):559-63. doi: 10.1016/j.jcv.2013.09.013. Epub 2013 Sep 20.
BACKGROUND
The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes.
OBJECTIVES
To investigate AF samples of PPROM pregnancies for the presence of viral genomes.
STUDY DESIGN
AF samples from patients with PPROM were collected during a 4-year (2008-2012) observational study. 174 women were included with selection criteria of singleton pregnancy, PPROM, and maternal age of 18 years and above. PCR was used for detection of human cytomegalovirus (HCMV), herpes simplex virus (HSV), parvovirus B19, human adenoviruses (HAdV), enteroviruses (EV) and human parechovirus (HPeV). The selection of these viral targets was based on literature regarding screening of AF for presence of viral genomes.
RESULTS
Only a single sample was positive out of the 174 tested AFs, HCMV DNA was detected.
CONCLUSIONS
PPROM is not associated with active viral infections.
背景
病毒感染在早产胎膜早破（PPROM）中的作用尚未确定。对合并 PPROM 妊娠的羊水（AF）中病毒基因组存在的研究结果存在矛盾。
目的
检测 PPROM 妊娠的 AF 样本中是否存在病毒基因组。
研究设计
在一项为期 4 年（2008-2012 年）的观察性研究中收集了 PPROM 患者的 AF 样本。纳入了 174 名符合以下标准的单胎妊娠、PPROM 和母亲年龄在 18 岁及以上的女性。采用 PCR 检测人巨细胞病毒（HCMV）、单纯疱疹病毒（HSV）、细小病毒 B19、人腺病毒（HAdV）、肠道病毒（EV）和人肠道病毒（HPeV）。选择这些病毒靶标是基于文献中关于筛查 AF 中病毒基因组存在的情况。
结果
在 174 份检测的 AF 样本中，仅 1 份呈阳性，检测到 HCMV DNA。
结论
PPROM 与活跃的病毒感染无关。
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