一名重型再生障碍性贫血患儿接受异基因造血干细胞移植后发生播散性微小根霉感染。
Disseminated Rhizopus microsporus infection following allogeneic hematopoietic stem cell transplantation in a child with severe aplastic anemia.
作者信息
Ye B, Yu D, Zhang X, Shao K, Chen D, Wu D, Zhang Y, Zhou Y, Shen Y, Yu Q
机构信息
Department of Hematology, The First Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, China.
出版信息
Transpl Infect Dis. 2013 Dec;15(6):E216-23. doi: 10.1111/tid.12144. Epub 2013 Oct 14.
Disseminated Rhizopus microsporus infections are uncommon in children and are resistant to echinocandin and azole antifungal agents. We describe a child with severe aplastic anemia who developed disseminated R. microsporus infection following allogeneic hematopoietic stem cell transplantation. R. microsporus was identified microscopically in the hepatic drain culture and was confirmed on the basis of 18S rRNA and 28S rRNA sequence analyses. The patient was treated successfully with hepatic drainage and amphotericin B deoxycholate.
播散性微小根毛霉感染在儿童中并不常见，且对棘白菌素和唑类抗真菌药物耐药。我们描述了一名患有严重再生障碍性贫血的儿童，在接受异基因造血干细胞移植后发生了播散性微小根毛霉感染。在肝引流培养物中通过显微镜鉴定出微小根毛霉，并基于18S rRNA和28S rRNA序列分析得到确认。该患者通过肝引流和两性霉素B脱氧胆酸盐成功治愈。
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