Sakamoto Hikaru, Itonaga Hidehiro, Sawayama Yasushi, Taguchi Jun, Saijo Tomomi, Kuwatsuka Sayaka, Hashisako Mikiko, Kinoshita Naoe, Oishi Masao, Doi Hanako, Kosai Kosuke, Nishimoto Katsutaro, Tanaka Katsumi, Yanagihara Katsunori, Mukae Hiroshi, Izumikawa Koichi, Miyazaki Yasushi
Department of Hematology, Nagasaki University Hospital, Japan.
Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Japan.
Intern Med. 2018;57(17):2567-2571. doi: 10.2169/internalmedicine.0474-17. Epub 2018 Sep 1.
We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.
我们在此报告一例异基因造血干细胞移植后发生的罕见口腔毛霉菌病病例。由微小根毛霉引起的口腔毛霉菌病在中性粒细胞恢复前表现为局限性左颊部粘膜炎,有一个1厘米的黑色病灶。开始使用脂质体两性霉素B进行联合治疗并进行了手术清创;然而,患者因进行性全身性毛霉菌病死亡。移植后患者口腔毛霉菌病的诊断和管理需要给予相当的关注,从而表明充分了解危险因素的重要性。