Department of Pediatrics, Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Acta Physiol (Oxf). 2014 Feb;210(2):296-306. doi: 10.1111/apha.12171. Epub 2013 Oct 28.
Intrauterine malnutrition predisposes the offspring towards the development of type 2 diabetes and cardiovascular disease. To explain this association, the Developmental Origins of Health and Disease hypothesis was introduced, meaning that subtle environmental changes during embryonic and foetal development can influence post-natal physiological functions. Different mechanisms, including epigenetics, are thought to be involved in this foetal programming, but the link between epigenetics and disease is missing. There is increasing evidence that ectopic lipid accumulation and/or lipotoxicity is induced by foetal programming. The aim of this review is to provide insights into the mechanisms underlying lipotoxicity through programming, which contributes to the increase in hepatic and cardiac metabolic risk.
子宫内营养不良使后代易患 2 型糖尿病和心血管疾病。为了解释这种关联，引入了健康与疾病的发育起源假说，即胚胎和胎儿发育过程中微妙的环境变化会影响出生后的生理功能。人们认为，包括表观遗传学在内的不同机制都与这种胎儿编程有关，但表观遗传学与疾病之间的联系尚不清楚。越来越多的证据表明，胎儿编程会引起异位脂质积累和/或脂毒性。本综述的目的是提供对通过编程导致的脂毒性机制的深入了解，这有助于增加肝脏和心脏的代谢风险。
