母亲肥胖对心血管疾病胎儿编程的影响。
Impact of maternal obesity on fetal programming of cardiovascular disease.
作者信息
Roberts Victoria H J, Frias Antonio E, Grove Kevin L
机构信息
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
出版信息
Physiology (Bethesda). 2015 May;30(3):224-31. doi: 10.1152/physiol.00021.2014.
Abstract
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.
摘要
子宫内环境是长期健康结果的关键决定因素；母亲代谢状态不佳和胎盘功能不全与这些长期健康风险密切相关。人类流行病学研究将母亲肥胖与后代成年后患心血管疾病联系起来，但在动物模型中的机制研究有限。在此，我们综述了与孕期肥胖对母亲的影响以及随后对胎儿心血管发育的影响相关的文献。
相似文献
1
Impact of maternal obesity on fetal programming of cardiovascular disease.母亲肥胖对心血管疾病胎儿编程的影响。
Physiology (Bethesda). 2015 May;30(3):224-31. doi: 10.1152/physiol.00021.2014.
2
[Epigenetics and Nutrition: maternal nutrition impacts on placental development and health of offspring].[表观遗传学与营养：母体营养对胎盘发育及后代健康的影响]
Biol Aujourdhui. 2015;209(2):175-87. doi: 10.1051/jbio/2015021. Epub 2015 Oct 29.
3
Experimental models of developmental programming: consequences of exposure to an energy rich diet during development.发育编程的实验模型：发育期间暴露于高热量饮食的后果
J Physiol. 2005 May 15;565(Pt 1):3-8. doi: 10.1113/jphysiol.2004.079756. Epub 2005 Feb 3.
4
Influence of maternal dysmetabolic conditions during pregnancy on cardiovascular disease.妊娠期间母体代谢异常对心血管疾病的影响。
J Cardiovasc Transl Res. 2009 Sep;2(3):277-85. doi: 10.1007/s12265-009-9108-7. Epub 2009 May 29.
5
Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis--2012 Curt Richter Award Winner.糖皮质激素过多与疾病的发育起源：对假说的二十年检验——2012 年 Curt Richter 奖得主。
Psychoneuroendocrinology. 2013 Jan;38(1):1-11. doi: 10.1016/j.psyneuen.2012.08.012. Epub 2012 Sep 19.
6
Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight.母体饮食诱导的肥胖会使成年雄性小鼠后代出现心血管功能障碍，且与当前体重无关。
Endocrinology. 2014 Oct;155(10):3970-80. doi: 10.1210/en.2014-1383. Epub 2014 Jul 22.
7
Review: The placenta is a programming agent for cardiovascular disease.综述：胎盘是心血管疾病的一种编程代理。
Placenta. 2010 Mar;31 Suppl(Suppl):S54-9. doi: 10.1016/j.placenta.2010.01.002. Epub 2010 Feb 9.
8
The Impact of Maternal Body Composition and Dietary Fat Consumption upon Placental Lipid Processing and Offspring Metabolic Health.母体身体成分和膳食脂肪摄入对胎盘脂质处理和后代代谢健康的影响。
Nutrients. 2020 Oct 3;12(10):3031. doi: 10.3390/nu12103031.
9
Developmental programming of obesity in mammals.哺乳动物肥胖的发育编程
Exp Physiol. 2007 Mar;92(2):287-98. doi: 10.1113/expphysiol.2005.032854. Epub 2006 Dec 14.
10
Role of placental nutrient sensing in developmental programming.胎盘营养感知在发育编程中的作用。
Clin Obstet Gynecol. 2013 Sep;56(3):591-601. doi: 10.1097/GRF.0b013e3182993a2e.
引用本文的文献
1
Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia.队列资料简介：基于澳大利亚悉尼的 BABY1000 前瞻性纵向出生队列研究的初步报告
BMJ Open. 2023 Jun 8;13(6):e068275. doi: 10.1136/bmjopen-2022-068275.
2
Maternal obesity in pregnancy and children's cardiac function and structure: A systematic review and meta-analysis of evidence from human studies.孕期母体肥胖与儿童心脏功能和结构：来自人体研究证据的系统评价和荟萃分析。
PLoS One. 2022 Nov 8;17(11):e0275236. doi: 10.1371/journal.pone.0275236. eCollection 2022.
3
The Cardiovascular Disease (CVD) Risk Continuum from Prenatal Life to Adulthood: A Literature Review.心血管疾病（CVD）风险连续体从胎儿期到成年期：文献综述。
Int J Environ Res Public Health. 2022 Jul 7;19(14):8282. doi: 10.3390/ijerph19148282.
4
Association of Maternal Gestational Weight Gain With Left Ventricle Geometry and Function in Offspring at 4 Years of Age: A Prospective Birth Cohort Study.母亲孕期体重增加与后代4岁时左心室几何形态及功能的关联：一项前瞻性出生队列研究
Front Pediatr. 2021 Aug 27;9:722385. doi: 10.3389/fped.2021.722385. eCollection 2021.
5
Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life.父母肥胖对后代生命早期心脏SIRT3表达、线粒体效率和舒张功能影响的性别差异。
Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H485-H495. doi: 10.1152/ajpheart.00176.2021. Epub 2021 Jul 23.
6
Maternal weight before and during pregnancy in women with gestational diabetes: one step forward, one step back.妊娠期糖尿病女性孕前及孕期的体重：前进一步，又后退一步。
J Pediatr (Rio J). 2021 Mar-Apr;97(2):112-115. doi: 10.1016/j.jped.2020.09.001. Epub 2020 Sep 25.
7
Adiposity and cardiovascular outcomes in three-year-old children of participants in UPBEAT, an RCT of a complex intervention in pregnant women with obesity.UPBEAT（一项针对肥胖孕妇的复杂干预随机对照试验）参与者三岁子女的肥胖与心血管结局
Pediatr Obes. 2021 Mar;16(3):e12725. doi: 10.1111/ijpo.12725. Epub 2020 Sep 11.
8
Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.母体糖尿病对胎儿心脏功能的超声心动图影响：系统评价和荟萃分析。
Ultrasound Obstet Gynecol. 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163.
9
Paternal Resistance Training Induced Modifications in the Left Ventricle Proteome Independent of Offspring Diet.父代抗阻训练诱导左心室蛋白质组改变，与子代饮食无关。
Oxid Med Cell Longev. 2020 May 4;2020:5603580. doi: 10.1155/2020/5603580. eCollection 2020.
10
Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates.母体肥胖和西式饮食破坏非人类灵长类动物胎儿和幼年后代骨骼肌胰岛素刺激的葡萄糖转运。
Diabetes. 2020 Jul;69(7):1389-1400. doi: 10.2337/db19-1218. Epub 2020 Apr 30.
本文引用的文献
1
Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight.母体饮食诱导的肥胖会使成年雄性小鼠后代出现心血管功能障碍，且与当前体重无关。
Endocrinology. 2014 Oct;155(10):3970-80. doi: 10.1210/en.2014-1383. Epub 2014 Jul 22.
2
The Human Placenta Project: placental structure, development, and function in real time.人类胎盘项目：实时观察胎盘的结构、发育及功能。
Placenta. 2014 May;35(5):303-4. doi: 10.1016/j.placenta.2014.02.012. Epub 2014 Mar 6.
3
The vascular endothelin system in obesity and type 2 diabetes: pathophysiology and therapeutic implications.肥胖与2型糖尿病中的血管内皮素系统：病理生理学及治疗意义
Life Sci. 2014 Nov 24;118(2):149-55. doi: 10.1016/j.lfs.2014.02.028. Epub 2014 Mar 7.
4
A review on the genetic, environmental, and lifestyle aspects of the early-life origins of cardiovascular disease.心血管疾病早期起源的遗传、环境和生活方式因素综述。
Curr Probl Pediatr Adolesc Health Care. 2014 Mar;44(3):54-72. doi: 10.1016/j.cppeds.2013.12.005.
5
Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates.在怀孕的非人类灵长类动物中补充白藜芦醇的有益和警示性结果。
FASEB J. 2014 Jun;28(6):2466-77. doi: 10.1096/fj.13-245472. Epub 2014 Feb 21.
6
Maternal obesity is associated with a lipotoxic placental environment.母亲肥胖与胎盘脂肪毒性环境有关。
Placenta. 2014 Mar;35(3):171-7. doi: 10.1016/j.placenta.2014.01.003. Epub 2014 Jan 11.
7
Maternal obesity impairs specific regulatory pathways in human myometrial arteries.孕妇肥胖会损害人体子宫肌层动脉中的特定调节途径。
Biol Reprod. 2014 Mar 27;90(3):65. doi: 10.1095/biolreprod.113.112623. Print 2014 Mar.
8
Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity.在终身母体肥胖的大鼠模型中，滋养细胞浸润和血管重塑发生改变。
Reprod Sci. 2014 May;21(5):648-57. doi: 10.1177/1933719113508815. Epub 2013 Oct 23.
9
Lipotoxicity and the role of maternal nutrition.脂毒性与母体营养的作用。
Acta Physiol (Oxf). 2014 Feb;210(2):296-306. doi: 10.1111/apha.12171. Epub 2013 Oct 28.
10
Influence of gestational overfeeding on myocardial proinflammatory mediators in fetal sheep heart.妊娠期过度喂养对胎羊心脏心肌促炎介质的影响。
J Nutr Biochem. 2013 Nov;24(11):1982-90. doi: 10.1016/j.jnutbio.2013.07.003. Epub 2013 Sep 26.
Zotero 插件