Roberts Victoria H J, Frias Antonio E, Grove Kevin L
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Physiology (Bethesda). 2015 May;30(3):224-31. doi: 10.1152/physiol.00021.2014.
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.
子宫内环境是长期健康结果的关键决定因素；母亲代谢状态不佳和胎盘功能不全与这些长期健康风险密切相关。人类流行病学研究将母亲肥胖与后代成年后患心血管疾病联系起来，但在动物模型中的机制研究有限。在此，我们综述了与孕期肥胖对母亲的影响以及随后对胎儿心血管发育的影响相关的文献。
