Hedner T, Persson B
J Cardiovasc Pharmacol. 1985;7 Suppl 7:S161-3. doi: 10.1097/00005344-198500077-00045.
The antihypertensive effect of ketanserin in combination with beta-adrenergic blockade was assessed in a double-blind crossover (4 weeks) manner in 10 patients with essential hypertension. The addition of ketanserin (40 mg b.i.d.) to optimal doses of beta-adrenergic blockers had significant antihypertensive effects compared with treatment with beta-adrenergic blockers alone. When followed for 24 h at steady-state conditions, ketanserin effectively reduced the blood pressure during a major part of the day, with maximal effect occurring at the time of the peak plasma concentration of ketanserin (1-2 h after tablet intake). Six patients initially reported a slight sedation during ketanserin treatment.
以双盲交叉（4周）方式评估了酮色林与β-肾上腺素能阻滞剂联合使用对10例原发性高血压患者的降压效果。与单独使用β-肾上腺素能阻滞剂治疗相比，在β-肾上腺素能阻滞剂的最佳剂量基础上加用酮色林（40mg，每日两次）具有显著的降压作用。在稳态条件下进行24小时监测时，酮色林在一天的大部分时间内有效降低血压，最大作用出现在酮色林血浆浓度峰值时（服药后1-2小时）。6例患者最初报告在酮色林治疗期间有轻微的镇静作用。
