酮色林单剂量与安慰剂治疗慢性稳定型心绞痛的比较。
Comparison of single doses of ketanserin and placebo in chronic stable angina.
作者信息
Cameron H A, Cameron C M, Ramsay L E
出版信息
Br J Clin Pharmacol. 1986 Jul;22(1):114-6.
Abstract
Single doses of ketanserin (20 or 40 mg) and placebo were compared in a double-blind cross-over study in 10 patients with chronic stable angina treated with a beta-adrenoceptor antagonist. Ketanserin had no significant effect on the exercise time to angina, the rate of ST segment depression, or the circulatory response to exercise. The 95% confidence limits indicate that ketanserin is unlikely to increase exercise time to angina by more than 20%.
摘要
在一项双盲交叉研究中，对10名接受β-肾上腺素能受体拮抗剂治疗的慢性稳定型心绞痛患者，比较了单次剂量的酮色林（20毫克或40毫克）和安慰剂的效果。酮色林对心绞痛发作的运动时间、ST段压低率或运动时的循环反应均无显著影响。95%置信区间表明，酮色林增加心绞痛发作运动时间的幅度不太可能超过20%。
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