7T MRI 显示早期阿尔茨海默病患者的大脑皮质微梗死。
Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease.
机构信息
Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
J Alzheimers Dis. 2014;39(1):163-7. doi: 10.3233/JAD-131040.
Cerebral microinfarcts (CMIs) are a common finding in neuropathological studies of aging and dementia. Recently, it has become possible to detect CMIs in vivo. We studied CMI occurrence in 29 patients with mild cognitive impairment or early Alzheimer's disease (AD) and 22 non-demented individuals on 7Tesla MRI. CMI occurrence in patients (55%) and controls (45%) was not significantly different. In patients, CMI number tended to be related to microbleed number (p = 0.07). This first in vivo study of CMIs in early AD does not confirm findings from autopsy studies. Further studies are needed to clarify the role of CMIs in AD.
脑微梗死（CMIs）是衰老和痴呆神经病理学研究中的常见发现。最近，已经可以在体内检测到 CMIs。我们在 7T MRI 上研究了 29 例轻度认知障碍或早期阿尔茨海默病（AD）患者和 22 名非痴呆个体的 CMI 发生情况。患者（55%）和对照组（45%）的 CMI 发生率无显著差异。在患者中，CMI 数量与微出血数量呈趋势相关（p=0.07）。这项关于早期 AD 中 CMIs 的首次体内研究并未证实尸检研究的结果。需要进一步研究来阐明 CMIs 在 AD 中的作用。
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