Yuzepchuk S A, Rozina E E, Kaptsova T I, Kulish E A
Acta Virol. 1975 Jul;19(4):305-10.
The degree of attenuation of mumps virus was studied in intracerebrally inoculated Macaca mulatta monkeys. The virulent Leningrad-3 strain and its attenuated variant as well as the attenuated Sophia-6 strain were used. The nature of pathological alterations in the neurons pointed to neurotropism of only the virulent strain. Morphological changes caused by attenuated and virulent strains in the brain structures, in the epithelium and glandular structures of the salivary glands differed considerably and may be used as a kind of markers of neurovirulence and the degree of attenuation of mumps virus strains.
在经脑内接种的恒河猴中研究了腮腺炎病毒的减毒程度。使用了强毒株列宁格勒-3株及其减毒变体以及减毒的索菲亚-6株。神经元中病理改变的性质表明只有强毒株具有嗜神经性。减毒株和强毒株在脑结构、唾液腺上皮和腺结构中引起的形态学变化有很大差异，可作为腮腺炎病毒株神经毒力和减毒程度的一种标志物。
