腮腺炎病毒对猴子侵袭性的研究。
Study of mumps virus invasiveness in monkeys.
作者信息
Rozina E E, Kaptsova T I, Sharova O K, Nikolaeva M A, Nesterova T P
出版信息
Acta Virol. 1984 Mar;28(2):107-13.
Invasiveness of mumps virus strains, differing in the degree of attenuation was studied in green and Macaca mulatta monkeys infected either into salivary glands or intramuscularly. Peripheral infection with all strains under study resulted in their penetration into CNS irrespective of the attenuation degree. Specific morphological changes were observed in the brain of monkeys as confirmed by detection of virus antigen using fluorescent antibodies (FA) staining. Morphological changes and time of virus antigen detection in the brain differed depending on the neurovirulence of the strains based on different degree of their attenuation.
在绿猴和恒河猴中，通过唾液腺或肌肉注射感染了不同减毒程度的腮腺炎病毒株，研究其侵袭性。无论减毒程度如何，所有研究的毒株外周感染均导致其侵入中枢神经系统。通过荧光抗体（FA）染色检测病毒抗原证实，在猴子大脑中观察到了特定的形态学变化。根据毒株不同程度的减毒所具有的不同神经毒力，大脑中的形态学变化和病毒抗原检测时间也有所不同。
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