小鼠迟发型超敏反应中流感病毒血凝素结合性T细胞
Influenza virus hemagglutinin-binding T cells in delayed hypersensitivity induced in mice.
作者信息
Ochałek T, Porwit-Bóbr Z
出版信息
Acta Microbiol Pol. 1985;34(2):155-8.
PMID:2412403
Abstract
The ability of spleen T cells from mice inoculated with influenza virus to transfer delayed hypersensitivity increases after 5 days culture in the presence of TCGF and influenza virus or its hemagglutinin. Enriched T cells have also a greater ability to bind viral hemagglutinin than cells which were not cultured and restimulated with either antigen. The results suggest the selection in vitro of specific antigen-binding T cells, able to transfer delayed hypersensitivity.
摘要
接种流感病毒的小鼠脾脏T细胞，在存在白细胞介素-2和流感病毒或其血凝素的情况下培养5天后，其传递迟发型超敏反应的能力增强。与未培养且未用任何一种抗原再次刺激的细胞相比，富集的T细胞结合病毒血凝素的能力也更强。结果提示在体外选择出了能够传递迟发型超敏反应的特异性抗原结合T细胞。
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