Chan Gloria, Farzan Abdolvahab, DeLay Josepha, McEwen Beverly, Prescott John F, Friendship Robert M
Department of Population Medicine (Chan, Farzan, Friendship); Animal Health Laboratory (DeLay, McEwen); and Department of Pathobiology (Prescott), University of Guelph, Guelph, Ontario.
Can J Vet Res. 2013 Oct;77(4):254-60.
Laboratory surveillance data from the Animal Health Laboratory, University of Guelph, on the etiological diagnoses of neonatal diarrhea in piglets were analyzed to determine the relative importance and trends of different enteric pathogens in Ontario. A total of 237 cases, including live and dead 1- to 7-day-old piglets, were submitted for diagnosis of gastrointestinal illness between 2001 and 2010. The combined frequencies for cases of gastrointestinal illness involving Escherichia coli, Clostridium perfringens type A, rotavirus, and Clostridium difficile, either as single pathogens or a complex of pathogens, accounted for 56% of the total cases. In a total of 33% of cases of gastrointestinal illness, an etiological agent was not identified. The frequency of cases diagnosed with enterotoxigenic E. coli was decreased from 2007. Cases submitted in 2010 were more likely to be diagnosed with C. perfringens type A compared to cases submitted in 2002 to 2007 (P < 0.05). There was a significant trend for cases submitted in the winter to be diagnosed with C. perfringens type A, enterotoxigenic E. coli, rotavirus, and Cystoisospora suis (formerly Isospora suis) (P < 0.05). Enterotoxigenic E. coli was less likely diagnosed if C. difficile, C. perfringens, or rotavirus were detected (P < 0.05). Younger piglets were more likely to be diagnosed with C. perfringens type A (P < 0.05) and C. difficile (P < 0.05) than older piglets. This study shows that E. coli, C. perfringens type A, rotavirus, and C. difficile are enteric pathogens of concern for Ontario swine farrowing operations and further research is required to understand the reasons for the cases that are not diagnosed.
对圭尔夫大学动物健康实验室关于仔猪新生腹泻病因诊断的实验室监测数据进行了分析，以确定安大略省不同肠道病原体的相对重要性和趋势。2001年至2010年间，共有237例病例（包括1至7日龄的活仔猪和死仔猪）因胃肠道疾病被送检诊断。涉及大肠杆菌、A型产气荚膜梭菌、轮状病毒和艰难梭菌的胃肠道疾病病例的综合频率，无论是单一病原体还是病原体复合体，占总病例数的56%。在总共33%的胃肠道疾病病例中，未鉴定出病原体。2007年后，诊断为产肠毒素大肠杆菌的病例频率有所下降。与2002年至2007年送检的病例相比，2010年送检的病例更有可能被诊断为A型产气荚膜梭菌（P < 0.05）。冬季送检的病例被诊断为A型产气荚膜梭菌、产肠毒素大肠杆菌、轮状病毒和猪等孢球虫（原猪等孢球虫）的趋势显著（P < 0.05）。如果检测到艰难梭菌、产气荚膜梭菌或轮状病毒，则产肠毒素大肠杆菌被诊断的可能性较小（P < 0.05）。与较大的仔猪相比，较小的仔猪更有可能被诊断为A型产气荚膜梭菌（P < 0.05）和艰难梭菌（P < 0.05）。这项研究表明，大肠杆菌、A型产气荚膜梭菌、轮状病毒和艰难梭菌是安大略省养猪场关注的肠道病原体，需要进一步研究以了解未确诊病例的原因。
