Gentry G A, Evans S, Campbell D E
Acta Virol. 1975 Sep;19(5):401-5.
Deoxyribonuclease I penetrates herpesvirus-infected L cells and degrades host DNA without interfering with viral multiplication. The DNA of uninfected control monolayers of L cells, disrupted by scraping, is similarly attacked. In contrast, undisturbed L cells are not affected. This suggests that altered cell membrane permeability allows the nuclease to enter the cell, thereby permitting access of exogenous deoxyribonuclease to cellular DNA.
脱氧核糖核酸酶I可穿透疱疹病毒感染的L细胞，并降解宿主DNA，而不干扰病毒繁殖。通过刮擦破坏的未感染L细胞对照单层的DNA也受到类似攻击。相比之下，未受干扰的L细胞则不受影响。这表明细胞膜通透性的改变使核酸酶能够进入细胞，从而使外源性脱氧核糖核酸酶能够接触到细胞DNA。
