Fogliani J, Capuccio P, Goudard A, Guillen J C, Monties J R
Ann Anesthesiol Fr. 1975 May-Jun;16(3):189-96.
The use of potassium canrenoate (Soludactone) in the post-operative period in 31 patients who had undergone open-heart surgery, in comparison with a control batch of patients, led to a more rapid and easier regression of myocardial hyperexcitability, the maintenance of kaliemia at values near normal, a reduction in kaliuresis, a rapid elevation of the urinary Na/K ratio and the maintenance of satisfactory diuresis. But the majority of these effects appear progressively during the first 3 days of treatment, so potassium canrenoate should be prescribed 3 days before the intervention so that the beneficial effects may be manifested from the day of the intervention itself.
对31例接受心脏直视手术的患者在术后使用坎利酸钾（索体舒通），并与对照组患者进行比较，结果显示，心肌过度兴奋的消退更快、更顺利，血钾水平维持在接近正常的值，尿钾排泄减少，尿钠/钾比值迅速升高，且利尿效果良好。但这些效果大多在治疗的前3天逐渐显现，因此坎利酸钾应在干预前3天给药，以便从干预当天就能显现出有益效果。
