Krimphove M, Opitz K
Arch Int Pharmacodyn Ther. 1975 Aug;216(2):328-50.
The calorigenic action of glucagon was studied in several species by measuring its effect on the oxygen comsumption. The calorigenic effect was most pronounced in the quail and also evident in young adult rats of two different strains but not in mice and guinea pigs. The influence of various drugs on the calorigenic effect of glucagon was investigated in rats. Ganglionic blocking agents (hexamethonium, mecamylamine, chlorisondamine) as well as adrenergic blocking drugs (propranolol, butoxamine, phentolamine) greatly reduced the glucagon-induced calorigenesis but after pretreatment with reserpine, guanethidine or chemical sympathectomy with 6-hydroxydopamine the calorigenic effect of glucagon was exaggerated. It was somewhat diminished by nicotinic acid but not by chlorpromazine or lithium and potentiated by cocaine but not by theophylline.--These results are not indicative for an involvement of adenly cyclase--cyclic AMP--system in glucagon-induced calorigenesis but they are compatible with the assumption that the hormone enhances the metabolic rate by releasing catecholamines from the adrenal medulla.
通过测量胰高血糖素对氧消耗的影响，在几个物种中研究了其产热作用。产热效应在鹌鹑中最为明显，在两种不同品系的成年幼鼠中也很明显，但在小鼠和豚鼠中不明显。在大鼠中研究了各种药物对胰高血糖素产热效应的影响。神经节阻断剂（六甲铵、美加明、氯异吲哚铵）以及肾上腺素能阻断药物（普萘洛尔、丁氧胺、酚妥拉明）大大降低了胰高血糖素诱导的产热，但在用利血平、胍乙啶预处理或用6-羟基多巴胺进行化学交感神经切除后，胰高血糖素的产热效应增强。烟酸使其有所减弱，但氯丙嗪或锂则无此作用，可卡因使其增强，但茶碱则无此作用。——这些结果并不表明腺苷酸环化酶 - 环磷腺苷系统参与了胰高血糖素诱导的产热，但它们与该激素通过从肾上腺髓质释放儿茶酚胺来提高代谢率的假设相符。
