Department of Radiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany.
PLoS One. 2013 Oct 9;8(10):e75263. doi: 10.1371/journal.pone.0075263. eCollection 2013.
To improve image and diagnostic quality in dynamic CT myocardial perfusion imaging (MPI) by using motion compensation and a spatio-temporal filter.
Dynamic CT MPI was performed using a 256-slice multidetector computed tomography scanner (MDCT). Data from two different patients-with and without myocardial perfusion defects-were evaluated to illustrate potential improvements for MPI (institutional review board approved). Three datasets for each patient were generated: (i) original data (ii) motion compensated data and (iii) motion compensated data with spatio-temporal filtering performed. In addition to the visual assessment of the tomographic slices, noise and contrast-to-noise-ratio (CNR) were measured for all data. Perfusion analysis was performed using time-density curves with regions-of-interest (ROI) placed in normal and hypoperfused myocardium. Precision in definition of normal and hypoperfused areas was determined in corresponding coloured perfusion maps.
The use of motion compensation followed by spatio-temporal filtering resulted in better alignment of the cardiac volumes over time leading to a more consistent perfusion quantification and improved detection of the extend of perfusion defects. Additionally image noise was reduced by 78.5%, with CNR improvements by a factor of 4.7. The average effective radiation dose estimate was 7.1±1.1 mSv.
The use of motion compensation and spatio-temporal smoothing will result in improved quantification of dynamic CT MPI using a latest generation CT scanner.
通过使用运动补偿和时空滤波器来提高动态 CT 心肌灌注成像（MPI）的图像和诊断质量。
使用 256 层多排 CT 扫描仪（MDCT）进行动态 CT MPI。评估了来自两名不同患者的两种数据（有和无心肌灌注缺损），以说明 MPI 的潜在改进（机构审查委员会批准）。为每位患者生成了三组数据集：（i）原始数据，（ii）运动补偿数据，（iii）运动补偿后进行时空滤波的数据。除了对断层图像进行视觉评估外，还测量了所有数据的噪声和对比噪声比（CNR）。使用感兴趣区（ROI）在正常和低灌注心肌中放置时间密度曲线进行灌注分析。在相应的彩色灌注图中确定正常和低灌注区域的定义精度。
使用运动补偿后进行时空滤波可使心脏容积在时间上更好地对齐，从而更一致地进行灌注定量，并提高灌注缺损程度的检测能力。此外，图像噪声降低了 78.5%，CNR 提高了 4.7 倍。平均有效辐射剂量估计值为 7.1±1.1 mSv。
使用运动补偿和时空平滑将导致使用最新一代 CT 扫描仪进行动态 CT MPI 的定量评估得到改善。
