Polyglutamation of methotrexate. Is methotrexate a prodrug?
作者信息
Chabner B A, Allegra C J, Curt G A, Clendeninn N J, Baram J, Koizumi S, Drake J C, Jolivet J
出版信息
J Clin Invest. 1985 Sep;76(3):907-12. doi: 10.1172/JCI112088.
Abstract
摘要
相似文献
1
Polyglutamation of methotrexate. Is methotrexate a prodrug?甲氨蝶呤的聚谷氨酸化。甲氨蝶呤是前药吗？
J Clin Invest. 1985 Sep;76(3):907-12. doi: 10.1172/JCI112088.
2
[Mechanisms of resistance to methotrexate].[甲氨蝶呤耐药机制]
Haematologica. 1991 Jun;76 Suppl 3:184-7.
3
Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.甲氨蝶呤多聚谷氨酸在人乳腺癌细胞中的细胞内药代动力学。4-氨基-10-甲基蝶酰谷氨酸4和4-氨基-10-甲基蝶酰谷氨酸5对二氢叶酸还原酶的选择性保留及较少的解离性结合。
J Clin Invest. 1983 Sep;72(3):773-8. doi: 10.1172/JCI111048.
4
Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.
Mol Pharmacol. 1980 Jan;17(1):105-10.
5
Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines.人软组织肉瘤细胞系对甲氨蝶呤的内在抗性
Cancer Res. 1992 Jul 15;52(14):3908-13.
6
The kinetics of methotrexate polyglutamation in human breast cancer cells.甲氨蝶呤在人乳腺癌细胞中的多聚谷氨酸化动力学
Arch Biochem Biophys. 1987 May 1;254(2):597-610. doi: 10.1016/0003-9861(87)90143-3.
7
8
9
Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer.人小细胞肺癌对甲氨蝶呤多聚谷氨酸的合成与潴留
Biochem Pharmacol. 1984 May 15;33(10):1682-5. doi: 10.1016/0006-2952(84)90292-2.
10
Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.甲氨蝶呤在正常及耐药大鼠肝癌培养细胞中的转运与代谢
Cancer Res. 1979 Mar;39(3):735-43.
引用本文的文献
1
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR-Induced AMPK Activation and Glucose Uptake in L6 Myotubes.多种从头嘌呤合成抑制剂促进AICAR诱导的L6肌管中AMPK激活和葡萄糖摄取。
Biofactors. 2025 Jul-Aug;51(4):e70037. doi: 10.1002/biof.70037.
2
Synthesis and In Vitro Pharmacological Evaluation of 5,8-Dideaza Analogs of Methotrexate.甲氨蝶呤5,8-二脱氮类似物的合成及体外药理评价
Molecules. 2025 Jun 27;30(13):2772. doi: 10.3390/molecules30132772.
3
Targeted proteomics in extracellular vesicles identifies biomarkers predictive for therapeutic response in sarcoidosis.细胞外囊泡中的靶向蛋白质组学可识别结节病治疗反应的预测生物标志物。
ERJ Open Res. 2025 Mar 3;11(2). doi: 10.1183/23120541.00672-2024. eCollection 2025 Mar.
4
Assessment of Erythrocytes Methotrexate Polyglutamate Three Levels in Psoriatic Patients Treated with Methotrexate Monotherapy and Their Association with Disease Response.甲氨蝶呤单药治疗的银屑病患者红细胞甲氨蝶呤多聚谷氨酸三级水平评估及其与疾病反应的关联
Indian J Clin Biochem. 2025 Jan;40(1):89-96. doi: 10.1007/s12291-024-01269-x. Epub 2024 Sep 18.
5
Comprehensive Parent-Metabolite PBPK/PD Modeling Insights Into Methotrexate Personalized Dosing Strategies in Patients With Rheumatoid Arthritis.类风湿关节炎患者甲氨蝶呤个体化给药策略的综合亲代-代谢物PBPK/PD建模见解
CPT Pharmacometrics Syst Pharmacol. 2025 Apr;14(4):695-705. doi: 10.1002/psp4.13305. Epub 2025 Jan 8.
6
Nanogel: A versatile drug delivery system for the treatment of various diseases and their future perspective.纳米凝胶：一种用于治疗多种疾病的多功能药物递送系统及其未来展望。
Drug Deliv Transl Res. 2025 Feb;15(2):455-482. doi: 10.1007/s13346-024-01684-w. Epub 2024 Aug 5.
7
The impact of the human gut microbiome on the treatment of autoimmune disease.人类肠道微生物组对自身免疫性疾病治疗的影响。
Immunol Rev. 2024 Aug;325(1):107-130. doi: 10.1111/imr.13358. Epub 2024 Jun 12.
8
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing.线粒体叶酸代谢的抑制通过mTORC1介导的嘌呤感知驱动分化。
Nat Commun. 2024 Mar 2;15(1):1931. doi: 10.1038/s41467-024-46114-0.
9
In vitro chemosensitivity testing of the feline large granular lymphocyte cell line (S87).猫大颗粒淋巴细胞系（S87）的体外化学敏感性测试
Vet Med Sci. 2024 Mar;10(2):e1350. doi: 10.1002/vms3.1350.
10
Association of microRNA Polymorphisms with Toxicities Induced by Methotrexate in Children with Acute Lymphoblastic Leukemia.微小RNA多态性与急性淋巴细胞白血病患儿甲氨蝶呤诱导的毒性反应的关联
Hematol Rep. 2023 Nov 20;15(4):634-650. doi: 10.3390/hematolrep15040065.
本文引用的文献
1
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.亚硝基脲处理的人肿瘤细胞中的DNA交联与单加合物修复
Nature. 1980 Dec 25;288(5792):727-9. doi: 10.1038/288727a0.
2
Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.叶酰聚谷氨酸的酶促合成。反应及其产物的表征。
J Biol Chem. 1980 Jun 25;255(12):5776-88.
3
4
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.用羟基脲处理小鼠3T6细胞增强甲氨蝶呤抗性及二氢叶酸还原酶基因扩增
Mol Cell Biol. 1983 Jun;3(6):1097-107. doi: 10.1128/mcb.3.6.1097-1107.1983.
5
Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells.细菌和哺乳动物细胞合成叶酰多聚-γ-谷氨酸
Mol Cell Biochem. 1981 Sep 25;39:209-28. doi: 10.1007/BF00232575.
6
Gene amplification in cultured animal cells.培养动物细胞中的基因扩增。
Cell. 1984 Jul;37(3):705-13. doi: 10.1016/0092-8674(84)90406-9.
7
8
Folypolyglutamate synthetase from beef liver: assay, stabilization, and characterization.
Can J Biochem Cell Biol. 1984 Jun;62(6):495-506. doi: 10.1139/o84-067.
9
10
Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer.人小细胞肺癌对甲氨蝶呤多聚谷氨酸的合成与潴留
Biochem Pharmacol. 1984 May 15;33(10):1682-5. doi: 10.1016/0006-2952(84)90292-2.
Zotero 插件