人小细胞肺癌对甲氨蝶呤多聚谷氨酸的合成与潴留 - Suppr

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Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer.

作者信息

Curt G A, Jolivet J, Bailey B D, Carney D N, Chabner B A

出版信息

Biochem Pharmacol. 1984 May 15;33(10):1682-5. doi: 10.1016/0006-2952(84)90292-2.

DOI:10.1016/0006-2952(84)90292-2

PMID:6203536

Abstract

摘要

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Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer.人小细胞肺癌对甲氨蝶呤多聚谷氨酸的合成与潴留

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Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.甲氨蝶呤多聚谷氨酰化受损是CCRF-CEM细胞在短期高剂量使用该药物后产生耐药性的一个原因。

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Synthesis and retention of methotrexate polyglutamates in Ehrlich ascites carcinoma cells.氨甲蝶呤聚谷氨酸盐在艾氏腹水癌细胞中的合成与潴留

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Methotrexate polyglutamates in cultured human cells.培养的人类细胞中的甲氨蝶呤多聚谷氨酸盐。

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Methotrexate polyglutamate synthesis by cultured human breast cancer cells.培养的人乳腺癌细胞中甲氨蝶呤多聚谷氨酸的合成

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Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.人小细胞肺癌细胞系对甲氨蝶呤敏感性的决定因素。

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Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7).甲氨蝶呤多聚谷氨酸与二氢叶酸在亚叶酸钙解救过程中于人类乳腺癌细胞系（MCF-7）中的相互作用

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The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells.甲氨蝶呤多聚谷氨酸盐在培养的人乳腺癌细胞中的合成与保留

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引用本文的文献

Treatment of the rat R-1 rhabdomyosarcoma with methotrexate and radiation; effects of timing on cell survival and tumour growth delay.用甲氨蝶呤和放疗治疗大鼠R-1横纹肌肉瘤；时间安排对细胞存活和肿瘤生长延迟的影响。

J Cancer Res Clin Oncol. 1993;119(4):215-20. doi: 10.1007/BF01624433.

Effect of methotrexate on intracellular folate pools in purified myeloid precursor cells from normal human bone marrow.甲氨蝶呤对来自正常人骨髓的纯化髓系前体细胞内叶酸池的影响。

J Clin Invest. 1987 Mar;79(3):692-7. doi: 10.1172/JCI112872.

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.正常人骨髓纯化髓系前体细胞中氨甲蝶呤多聚谷氨酸盐的形成。

J Clin Invest. 1985 Mar;75(3):1008-14. doi: 10.1172/JCI111761.

Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.甲氨蝶呤（MTX）耐药的K562细胞系中甲氨蝶呤（MTX）-多聚谷氨酸形成受损。

Jpn J Cancer Res. 1988 Nov;79(11):1230-7. doi: 10.1111/j.1349-7006.1988.tb01549.x.

Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.人小细胞肺癌细胞系对甲氨蝶呤敏感性的决定因素。

J Clin Invest. 1985 Oct;76(4):1323-9. doi: 10.1172/JCI112106.

Polyglutamation of methotrexate. Is methotrexate a prodrug?甲氨蝶呤的聚谷氨酸化。甲氨蝶呤是前药吗？

J Clin Invest. 1985 Sep;76(3):907-12. doi: 10.1172/JCI112088.

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