Park J-E, Oh S-H, Cha Y-S
Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, Korea; Jeonju Makgeolli Research Center, Chonbuk National University, Jeonju, Korea.
J Appl Microbiol. 2014 Jan;116(1):145-56. doi: 10.1111/jam.12354. Epub 2013 Oct 16.
This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik-hae.
Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high-fat diet & DW), LGLAB (high-fat diet & Lactobacillus plantarum LG42, 1 × 10(7) CFU per mouse), HGLAB (high-fat diet & L. plantarum LG42, 1 × 10(9) CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT-I were significantly increased in GLAB groups, whereas the level of ACC, SREBP-1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high-fat-diet-induced obese mice.
These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.
本研究调查了从加贾米食醋中分离出的乳酸菌（植物乳杆菌LG42）的抗肥胖作用。
将雄性C57BL/6J小鼠分为四组（n = 10）；正常饮食组（NDC，正常饮食与蒸馏水）、高脂饮食组（HDC，高脂饮食与蒸馏水）、低剂量乳酸菌组（LGLAB，高脂饮食与植物乳杆菌LG42，每只小鼠1×10⁷CFU）、高剂量乳酸菌组（HGLAB，高脂饮食与植物乳杆菌LG42，每只小鼠1×10⁹CFU）。12周后，补充乳酸菌的组体重较低，附睾和背部脂肪显著减少。补充乳酸菌的组血清和肝脏甘油三酯、血清胰岛素和瘦素水平显著降低。与高脂饮食组相比，补充乳酸菌的组肝脏中PPARα和CPT - I的mRNA表达显著增加，而ACC、SREBP - 1和LXRα的水平显著降低。此外，乳酸菌降低了附睾脂肪组织中PPARγ的表达，从而抑制了受PPARγ调控的基因。
这些结果表明植物乳杆菌LG42对高脂饮食诱导的肥胖小鼠具有抗肥胖作用。
这些结果可能有助于营养保健品和食品行业开发基于功能性食品和益生菌的肥胖治疗与预防疗法。
