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韩国动态血压监测登记研究:中心性肥胖与血压昼夜节律参数的相关性。

Association between central obesity and circadian parameters of blood pressure from the korean ambulatory blood pressure monitoring registry: Kor-ABP registry.

机构信息

Division of Cardiology, Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.

出版信息

J Korean Med Sci. 2013 Oct;28(10):1461-7. doi: 10.3346/jkms.2013.28.10.1461. Epub 2013 Sep 25.


DOI:10.3346/jkms.2013.28.10.1461
PMID:24133350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3792600/
Abstract

Central obesity has been reported as a risk for atherosclerosis and metabolic syndrome. The influence of central obesity on diurnal blood pressure (BP) has not been established. In this study, we investigated the influence of central obesity on the circadian parameters of BP by 24 hr ambulatory BP monitoring. Total 1,290 subjects were enrolled from the Korean Ambulatory BP registry. Central obesity was defined as having a waist circumference≥90 cm in males and ≥85 cm in females. The central-obese group had higher daytime systolic BP (SBP), nighttime SBP and diastolic BP (DBP) than the non-obese group (all, P<0.001). There were no differences in nocturnal dipping (ND) patterns between the groups. Female participants showed a higher BP mean difference (MD) than male participants with concerns of central obesity (daytime SBP MD 5.28 vs 4.27, nighttime SBP MD 6.48 vs 2.72) and wider pulse pressure (PP). Central obesity within the elderly (≥65 yr) also showed a higher BP MD than within the younger group (daytime SBP MD 8.23 vs 3.87, daytime DBP 4.10 vs 1.59). In conclusion, central obesity has no influence on nocturnal dipping patterns. However, higher SBP and wider PP are associated with central obesity, which is accentuated in women.

摘要

中心性肥胖与动脉粥样硬化和代谢综合征的发生风险相关。中心性肥胖对日间血压(BP)昼夜节律的影响尚未明确。本研究通过 24 小时动态血压监测,探讨了中心性肥胖对 BP 昼夜节律参数的影响。共纳入 1290 名来自韩国动态血压登记处的受试者。中心性肥胖定义为男性腰围≥90cm,女性腰围≥85cm。与非肥胖组相比,中心性肥胖组的日间收缩压(SBP)、夜间 SBP 和舒张压(DBP)更高(均 P<0.001)。两组间夜间血压下降模式无差异。有中心性肥胖的女性参与者的 BP 平均差值(MD)高于男性参与者(日间 SBP MD 为 5.28 比 4.27,夜间 SBP MD 为 6.48 比 2.72),脉压(PP)更宽。≥65 岁的老年人群中,中心性肥胖患者的日间 SBP MD (8.23 比 3.87)和日间 DBP MD(4.10 比 1.59)也更高。综上,中心性肥胖对夜间血压下降模式无影响。然而,中心性肥胖与较高的 SBP 和更宽的 PP 相关,且在女性中更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/6dbdc609b86a/jkms-28-1461-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/64c2f52624ad/jkms-28-1461-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/e46991648118/jkms-28-1461-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/6dbdc609b86a/jkms-28-1461-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/64c2f52624ad/jkms-28-1461-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/e46991648118/jkms-28-1461-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29eb/3792600/6dbdc609b86a/jkms-28-1461-g003.jpg

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本文引用的文献

[1]
Sleep-time blood pressure: prognostic value and relevance as a therapeutic target for cardiovascular risk reduction.

Chronobiol Int. 2012-10-25

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Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes.

Chronobiol Int. 2012-10-25

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Resistant hypertension in visceral obesity.

Eur J Intern Med. 2012-5-15

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A controlled clinical trial of the effect of gastric bypass surgery and intensive lifestyle intervention on nocturnal hypertension and the circadian blood pressure rhythm in patients with morbid obesity.

Surgery. 2012-1-18

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