Kurbanov Kh, Charyeva G Kh, Novgorodskaia A M
Vopr Med Khim. 1983 Jul-Aug;29(4):69-73.
Activities of tyrosine aminotransferase and phenylalanine hydroxylase were studied in rat liver tissue in hyperthermia. Effects of heliothermic and laboratory chamber heating treatments were studied using intact animals and the rats preadministered with the enzyme substrates or hydrocortisone and with a mixture containing the substrates and hydrocortisone. The hyperthermia led to activation of tyrosine aminotransferase and to inhibition of phenylalanine hydroxylase in liver tissue. More distinct alterations in the enzymatic activity were observed after heliothermic treatment as compared with the chamber heating. Tyrosine aminotransferase and phenylalanine hydroxylase of liver tissue, which are involved in regulation of tyrosine content in the body, appear to maintain the coll homeostasis under conditions of external high temperature.
研究了高温状态下大鼠肝脏组织中酪氨酸转氨酶和苯丙氨酸羟化酶的活性。使用完整动物以及预先给予酶底物、氢化可的松或同时给予底物与氢化可的松混合物的大鼠，研究了日光热疗和实验室箱式加热处理的效果。高温导致肝脏组织中酪氨酸转氨酶激活以及苯丙氨酸羟化酶抑制。与箱式加热相比，日光热疗后酶活性的变化更明显。参与体内酪氨酸含量调节的肝脏组织中的酪氨酸转氨酶和苯丙氨酸羟化酶，似乎在外部高温条件下维持了体内平衡。
