Oxford Health NHS Foundation Trust, Oxford, UK,
Soc Psychiatry Psychiatr Epidemiol. 2014 Apr;49(4):651-63. doi: 10.1007/s00127-013-0781-0. Epub 2013 Oct 18.
The evidence regarding community treatment order effectiveness has been conflicting. This systematic review aims to bring up to date the review performed by Churchill and colleagues in 2005 by assessing and interpreting evidence of CTO effectiveness defined by admission rates, number of inpatient days, community service use, and medication adherence published since 2006.
Databases were searched to obtain relevant studies published from January 2006 to March 2013.
18 studies including one randomised controlled trial were included. There remains lack of evidence from randomised and non-randomised studies that CTOs are associated with or affected by admission rates, number of inpatient days or community service use. The most recent and largest RCT is included in this review and found no significant impact on admission rate (RR = 1.0, 95% CI 0.75-1.33) or number of days in hospital (IR = 0.90, 95% CI 0.65-1.26). Results from the two largest longitudinal datasets included in this review do not concur. Studies using the New York dataset found that CTOs were associated with reduced admission rates and inpatient days, while studies using the Victoria dataset generally found that they were associated with increased admission rates and inpatient days.
There is now robust evidence in the literature that CTOs have no significant effects on hospitalisation and other service use outcomes. Non-randomised studies continue to report conflicting results. Distinguishing between CTO recall and revocation and different patterns of community contact is needed in future research to ensure differentiation between CTO process and outcome.
有关社区治疗令有效性的证据一直存在争议。本系统评价旨在通过评估和解释自 2006 年以来发表的有关入院率、住院天数、社区服务使用和药物依从性的 CTO 有效性的证据,更新 Churchill 及其同事在 2005 年进行的综述。
检索数据库以获取 2006 年 1 月至 2013 年 3 月发表的相关研究。
共纳入 18 项研究,包括 1 项随机对照试验。目前仍缺乏随机和非随机研究的证据表明 CTO 与入院率、住院天数或社区服务使用相关或受其影响。本综述纳入了最新和最大的 RCT,发现 CTO 对入院率(RR=1.0,95%CI 0.75-1.33)或住院天数(IR=0.90,95%CI 0.65-1.26)没有显著影响。本综述中纳入的两个最大的纵向数据集的结果不一致。使用纽约数据集的研究发现 CTO 与入院率和住院天数降低相关,而使用维多利亚数据集的研究通常发现 CTO 与入院率和住院天数增加相关。
目前文献中有强有力的证据表明 CTO 对住院和其他服务使用结果没有显著影响。非随机研究仍报告相互矛盾的结果。未来的研究需要区分 CTO 的回忆和撤销以及不同的社区接触模式,以确保区分 CTO 过程和结果。