Johnson E H, Hietala S, Smith B P
Vet Microbiol. 1985 Aug;10(5):451-64. doi: 10.1016/0378-1135(85)90027-6.
Chemiluminescence of bovine alveolar macrophages was used to study the development of opsonins in calves vaccinated parenterally with live aromatic-dependent strains of either S. dublin or S. typhimurium. These calves responded by producing Salmonella-specific opsonins detected by increased chemiluminescent responses, and were able to survive oral challenge with live virulent organisms of either serotype. Non-vaccinated calves of the same age lacked Salmonella-specific opsonins and were not able to survive challenge. Thus it was concluded that the ability to produce opsonins is among the immunological responses that are associated with protection against salmonellosis in calves. Antigenic similarities between S. dublin and S. typhimurium were shown by the ability of either organism to absorb significant amounts of opsonic capacity from the sera of calves vaccinated with either of the two vaccines. These antigenic similarities are thought to explain in part the ability of either vaccine to protect against challenge with either the homologous or heterologous Salmonella serotype.
利用牛肺泡巨噬细胞的化学发光来研究经肠胃外接种都柏林沙门氏菌或鼠伤寒沙门氏菌的芳香族依赖活菌株疫苗的犊牛中调理素的产生情况。这些犊牛通过产生沙门氏菌特异性调理素来做出反应，这可通过化学发光反应增强来检测，并且能够在口服感染任一血清型的活的有毒力生物体的情况下存活。相同年龄的未接种疫苗的犊牛缺乏沙门氏菌特异性调理素，无法在感染后存活。因此得出结论，产生调理素的能力是与犊牛抗沙门氏菌病保护相关的免疫反应之一。都柏林沙门氏菌和鼠伤寒沙门氏菌之间的抗原相似性通过任一生物体从接种两种疫苗之一的犊牛血清中吸收大量调理能力得以体现。这些抗原相似性被认为部分解释了任一疫苗针对同源或异源沙门氏菌血清型感染的保护能力。
