Smith B P, Reina-Guerra M, Stocker B A, Hoiseth S K, Johnson E H
Am J Vet Res. 1984 Sep;45(9):1858-61.
Ten Holstein calves were divided into 2 groups. Five calves served as nonvaccinated controls, and 5 calves were vaccinated IM at 2 and 3 weeks of age with 10(9) aromatic-dependent (aro-) Salmonella typhimurium strain SL1479 containing O antigens 1, 4, 12. Serious adverse reactions to vaccination were not observed in the calves. Mean maximum rectal temperature increase in the vaccinated calves was 1.5 C. One calf had diarrhea and depressed appetite for 1 day after vaccination. At 5 weeks of age, all calves were challenge exposed orally with 1.5 X 10(11) virulent S dublin strain SL1367 (O antigens 9,12). After challenge-exposure inoculum was given, 1 of 5 vaccinated calves died and 4 of the 5 nonvaccinated calves died (P less than 0.05). Thus, some cross serotype protection against S dublin was induced by parenteral vaccination of calves with aro- S typhimurium strain SL1479, although protection was not complete.
十头荷斯坦犊牛被分为两组。五头犊牛作为未接种疫苗的对照组，另外五头犊牛在2周龄和3周龄时通过肌肉注射接种含O抗原1、4、12的10⁹芳香族依赖型（aro-）鼠伤寒沙门氏菌菌株SL1479。犊牛未观察到对疫苗接种的严重不良反应。接种疫苗的犊牛平均最大直肠温度升高1.5摄氏度。一头犊牛在接种疫苗后出现腹泻和食欲减退1天。在5周龄时，所有犊牛经口用1.5×10¹¹强毒都柏林沙门氏菌菌株SL1367（O抗原9、12）进行攻毒暴露。给予攻毒暴露接种物后，5头接种疫苗的犊牛中有1头死亡，5头未接种疫苗的犊牛中有4头死亡（P<0.05）。因此，用aro-鼠伤寒沙门氏菌菌株SL1479对犊牛进行肌肉注射接种可诱导对都柏林沙门氏菌的一些交叉血清型保护，尽管保护并不完全。
