Maier Gabriele Ute, Breitenbuecher Jefferson, Gomez Jose Pablo, Samah Festus, Fausak Erik, Van Noord Megan
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, 1 Shields Ave, Davis, CA, 95616, USA.
University Library, University of California, Davis, 1 Shields Ave, Davis, CA, 95616, USA.
Vet Anim Sci. 2022 Feb 19;15:100238. doi: 10.1016/j.vas.2022.100238. eCollection 2022 Mar.
Neonatal calf diarrhea (NCD), also known as scours, is an important disease of preweaned calves that affects the production and welfare of beef herds. While hygiene and nutrition are important in reducing the incidence of NCD, vaccination of dams or calves is often employed for the prevention of NCD. The present scoping review summarizes the available peer-reviewed scientific English literature on vaccination of dams or calves for the prevention of NCD over the past decades. The online databases Medline, CAB Abstracts, and Biosis were searched for articles on the topic published between 1950 and 2020. Online software was used to systematically evaluate 2807 citations for inclusion through pre-determined criteria in a 2-step process. In the 113 articles included in the review, vaccines tested targeted the pathogens (n = 43), bovine rotavirus (BRV, n = 38), (n = 29), bovine coronavirus (BCV, n = 14), bovine viral diarrhea virus (n= 7), and other pathogens (n = 8). Field trials for commercial vaccines have been published for the most important pathogens, and results on efficacy are variable for such vaccines targeting BRV, BCV, and Meta-analyses exploring efficacy of these vaccines would be helpful to practitioners and producers. No field studies on commercial products have shown efficacy for vaccines so that a meta-analysis would unlikely come to a different conclusion. Further research is needed on vaccines for protozoal pathogens like as well as on the importance of several emerging enteric viruses in calves.
新生犊牛腹泻（NCD），也称为腹泻，是断奶前犊牛的一种重要疾病，会影响肉牛群的生产和健康。虽然卫生和营养对于降低NCD的发病率很重要，但通常采用给母牛或犊牛接种疫苗的方法来预防NCD。本综述总结了过去几十年间关于给母牛或犊牛接种疫苗预防NCD的同行评审的英文科学文献。检索了在线数据库Medline、CAB文摘和Biosis，以查找1950年至2020年间发表的关于该主题的文章。使用在线软件通过两步预先确定的标准系统地评估2807条引文以纳入研究。在纳入综述的113篇文章中，所测试的疫苗针对的病原体包括（n = 43）、牛轮状病毒（BRV，n = 38）、（n = 29）、牛冠状病毒（BCV，n = 14）、牛病毒性腹泻病毒（n = 7）以及其他病原体（n = 8）。已经发表了针对最重要病原体的商业疫苗的田间试验，针对BRV、BCV和的此类疫苗的疗效结果各不相同。探索这些疫苗疗效的荟萃分析将有助于从业者和生产者。没有关于商业产品的田间研究表明疫苗有效，因此荟萃分析不太可能得出不同的结论。对于像这样的原生动物病原体的疫苗以及几种新兴肠道病毒在犊牛中的重要性，还需要进一步研究。
