Kou Yu-Hui, Zhang Pei-Xun, Dang Yu, Wei Shao-Yin, Wang Zhi-Yong, Zhang Dian-Ying, Fu Zhong-Guo, Jiang Bao-Guo
Department of Trauma and Orthopeadics, Peking University Peoples Hospital;Peking University Traffic Medicine Center, Beijing 100044, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2013 Oct 18;45(5):830-3.
Treatment of peripheral nerve injury is a major challenge in clinical practice. With advances in molecular biology and development of microsurgical techniques and tissue engineering, peripheral nerve repair procedures have been greatly improved. In the last 10 decades, most treatments for peripheral nerve injury in animal models have achieved histological and functional recovery, the treatments in humans, however, produce insufficient recovery, especially for proximal nerve injury. Increasing attention has been paid to the Traditional Chinese Medicine (TCM) for promoting peripheral nerve regeneration, since these remedies often display effective clinical outcome, minor side effects and effectiveness for multiple targets. Although TCM has complex ingredients and the specific pharmacological mechanisms for their effectiveness are still unclear, an effective clinical outcome is welcomed by many clinicians. In the past 20 years, we have made a series of detailed studies including the toxicity tests, pharmacodynamic tests, pharmacological experiments etc, about a new traditional formula which mainly contains the Radix hedysari, Epimedium etc. RESULTS have shown that this formula is safe to be used in both animals and humans with no toxicity and adverse effect, and systemic administration of this formula could enhance the peripheral nerve regeneration.
周围神经损伤的治疗是临床实践中的一项重大挑战。随着分子生物学的进步以及显微外科技术和组织工程的发展，周围神经修复手术有了很大改进。在过去的十年里，动物模型中大多数周围神经损伤的治疗都实现了组织学和功能恢复，然而，人类的治疗效果却不尽如人意，尤其是对于近端神经损伤。促进周围神经再生的传统中药受到了越来越多的关注，因为这些药物通常显示出有效的临床效果、轻微的副作用以及多靶点有效性。尽管中药成分复杂，其有效性的具体药理机制仍不清楚，但有效的临床结果受到了许多临床医生的欢迎。在过去的20年里，我们对一种主要含有红芪、淫羊藿等的新传统配方进行了一系列详细研究，包括毒性试验、药效学试验、药理学实验等。结果表明，该配方在动物和人类中使用都是安全的，没有毒性和不良反应，并且全身给药该配方可以促进周围神经再生。
