Nerve Regeneration Group, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.
Int Rev Neurobiol. 2013;108:223-56. doi: 10.1016/B978-0-12-410499-0.00009-5.
Neuregulin 1 (NRG1) is a multifunctional and versatile protein: its numerous isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. Accordingly, the use of NRG1 in vivo has already yielded encouraging results. The aim of this review is to focus on the role played by the different NRG1 isoforms during peripheral nerve regeneration and remyelination and to identify good candidates to be used for the development of tissue engineered medical devices delivering NRG1, with the objective of promoting better nerve repair.
神经调节蛋白 1（NRG1）是一种多功能且用途广泛的蛋白质：其众多同种型可以旁分泌、自分泌或近分泌方式发出信号，在外周神经系统发育和神经修复过程中发挥着重要作用，这表明 NRG1 的治疗可能会改善损伤后的功能结果。因此，NRG1 在体内的应用已经产生了令人鼓舞的结果。本综述的目的是关注不同 NRG1 同种型在外周神经再生和髓鞘再生过程中所起的作用，并确定可用于开发递送 NRG1 的组织工程医疗器械的良好候选物，以促进更好的神经修复。
