Charles Luenda E, Andrew Michael E, Sarkisian Khachatur, Shengqiao Li, Mnatsakanova Anna, Violanti John M, Wilson Mark, Gu Ja K, Miller Diane B, Burchfiel Cecil M
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
Am J Hum Biol. 2014 Jan-Feb;26(1):56-63. doi: 10.1002/ajhb.22475. Epub 2013 Oct 18.
Low heart rate variability (HRV) has been linked to cardiovascular disease. Our objective was to examine the cross-sectional association between insulin and HRV.
Insulin levels were measured in 355 nondiabetic officers from the BCOPS study, following a 12 h fast. HRV was performed according to methods published by the task force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high (HF) and low frequency (LF) HRV were compared across tertiles of insulin using ANOVA and ANCOVA; p-values were obtained from linear regression models.
Higher mean levels of insulin were significantly associated with lower (i.e., worse) mean levels of HRV before and after risk-factor adjustment. The results for HF HRV (ms(2)) were as follows: 1st insulin (µU/ml) tertile (156.3; 95% confidence interval (CI) = 128.6-189.9); 2nd tertile (154.3; 95% CI = 124.3-191.5); 3rd tertile (127.9; 95% CI = 105.0-155.8), p for trend = 0.017. Results with LF HRV were similar to HF HRV. Insulin was also inversely and significantly associated with HRV among officers with BMI ≥ 25 kg/m(2), with ≥ 25.5% body fat, and among those who reported low (<median) physical activity scores.
In this cohort, insulin levels were inversely and significantly associated with both HF and LF HRV, especially among those with higher levels of obesity and lower levels of physical activity, suggesting associations with autonomic nervous system function. Prospective studies of this association in other populations are warranted.
心率变异性（HRV）降低与心血管疾病相关。我们的目的是研究胰岛素与HRV之间的横断面关联。
在BCOPS研究中，对355名非糖尿病官员进行12小时禁食后测量胰岛素水平。HRV根据欧洲心脏病学会和北美心脏起搏与电生理学会特别工作组发表的方法进行测量和分析。使用方差分析（ANOVA）和协方差分析（ANCOVA）比较胰岛素三分位数组间的高频（HF）和低频（LF）HRV平均值；P值通过线性回归模型获得。
在调整危险因素前后，较高的胰岛素平均水平与较低（即较差）的HRV平均水平显著相关。HF HRV（ms²）的结果如下：第一胰岛素（µU/ml）三分位数组（156.3；95%置信区间（CI）=128.6 - 189.9）；第二三分位数组（154.3；95%CI = 124.3 - 191.5）；第三三分位数组（127.9；95%CI = 105.0 - 155.8），趋势P值 = 0.017。LF HRV的结果与HF HRV相似。在体重指数（BMI）≥25 kg/m²、体脂≥25.5%的官员以及报告低（<中位数）体力活动得分的官员中，胰岛素也与HRV呈显著负相关。
在该队列中，胰岛素水平与HF和LF HRV均呈显著负相关，尤其是在肥胖程度较高和体力活动水平较低的人群中，提示与自主神经系统功能有关。有必要在其他人群中对这种关联进行前瞻性研究。
