Kim Yong-Woo, Kim Hak Jin, Choi Seon Hee, Kim Dong Chan
Department of Radiology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Department of Radiology, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan, Republic of Korea
Acta Radiol. 2014 Oct;55(8):1008-14. doi: 10.1177/0284185113508181. Epub 2013 Oct 17.
The multiple prominent hypointense veins on susceptibility-weighted imaging (SWI) have been found in the ischemic territory of patients with acute ischemic stroke. Venous side is the unknown area in the hemodynamics of brain infarction.
To evaluate the venous aspect in acute brain infarction through an animal study.
The acute infarction in cat brains was induced with a bolus infusion of 0.25 mL of triolein through one side of the common carotid artery. The magnetic resonance (MR) images, including diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) map, SW, and perfusion-weighted (PWI) images, were obtained serially at 2 h (n = 17), 1 day (n = 11), and 4 days (n = 4) after triolein infusion. The obtained MR images were evaluated qualitatively and quantitatively. For qualitative assessment, the signal intensity of the serial MR images was evaluated. The presence or absence and the location with serial changes of infarction were identified on DWI and ADC map images. The presence or absence of prominent hypointense veins and the serial changes of cortical veins were also evaluated on SWI. Quantitative assessment was performed by comparing the relative cerebral blood volume (rCBV), cerebral blood flow (rCBF), and mean transit times (MTT) of the lesions with those of the contralateral normal side calculated on PWI. The serial changes of rCBV, rCBF, and MTT ratio were also evaluated.
Acute infarction in the first and second medial gyrus of lesion hemisphere was found by qualitative evaluation of DWI and ADC map images. On the serial evaluation of SWI, the cortical veins of cat brain with infarction were obscured at 2 h and then re-appeared at 1 day. The hemorrhage transformation and prominent hypointense veins were seen at 4 days on SWI. The quantitative evaluation revealed increased MTT ratios and decreased rCBV and rCBF ratios on PWIs in the acute infarction of cat brain.
The prominent hypointense veins on SWI were seen in the half of the acute infarction at 4 days. The prominent hypointense veins on SWI may have good agreement with the increased MTT ratio.
在急性缺血性脑卒中患者的缺血区域，磁共振血管造影（SWI）上发现多条明显的低信号静脉。在脑梗死的血流动力学中，静脉侧是一个未知领域。
通过动物研究评估急性脑梗死中的静脉情况。
通过一侧颈总动脉一次性注入0.25 mL三油酸甘油酯诱导猫脑急性梗死。在注入三油酸甘油酯后2小时（n = 17）、1天（n = 11）和4天（n = 4）连续获取磁共振（MR）图像，包括扩散加权成像（DWI）、表观扩散系数（ADC）图、SWI和灌注加权（PWI）图像。对获取的MR图像进行定性和定量评估。对于定性评估，评估连续MR图像的信号强度。在DWI和ADC图图像上确定梗死的存在与否及其连续变化的位置。在SWI上也评估明显低信号静脉的存在与否以及皮质静脉的连续变化。通过比较病变的相对脑血容量（rCBV）、脑血流量（rCBF）和平均通过时间（MTT）与在PWI上计算的对侧正常侧的值进行定量评估。还评估rCBV、rCBF和MTT比值的连续变化。
通过对DWI和ADC图图像的定性评估，发现病变半球的第一和第二内侧回有急性梗死。在SWI的连续评估中，梗死猫脑的皮质静脉在2小时时模糊不清，然后在1天时重新出现。在SWI上，4天时可见出血转化和明显的低信号静脉。定量评估显示，猫脑急性梗死的PWI上MTT比值增加，rCBV和rCBF比值降低。
在4天的急性梗死中，SWI上可见明显的低信号静脉。SWI上明显的低信号静脉可能与MTT比值增加具有良好的一致性。
