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由髂耻滑囊炎伴类风湿性髋关节破坏引起的下肢淋巴水肿:一例报告。

Leg lymphedema caused by iliopectineal bursitis associated with destruction of a rheumatoid hip joint: A case report.

作者信息

Kuroyanagi Gen, Yamada Kunio, Imaizumi Tsukasa, Mizutani Jun, Wada Ikuo, Kozawa Osamu, Tokuda Haruhiko, Otsuka Takanobu

机构信息

Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601; ; Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194;

出版信息

Exp Ther Med. 2013 Oct;6(4):887-890. doi: 10.3892/etm.2013.1243. Epub 2013 Aug 2.

Abstract

The present study describes a case of leg lymphedema due to iliopectineal bursitis associated with rheumatoid arthritis (RA), which was satisfactorily controlled by surgery and combination therapy with methotrexate (MTX) and tacrolimus. A 68-year-old male, who had a six-year history of RA, developed an iliopectineal bursa associated with destruction of the hip joint. The mass gradually increased in size, and there was swelling in his right lower extremity. The patient was subsequently hospitalized with increasing right hip pain and leg edema. A colorless transparent lymph fluid leaked from his leg, and leg lymphedema was thus diagnosed. The patient also had a 20-year history of myelodysplastic syndrome. Therefore, the extensive or total resection of the bursa was considered to be too invasive, so a partial bursal excision was performed via an anterior approach. Following the partial bursal excision, total hip arthroplasty (THA) was performed using the Hardinge approach. The leg lymphedema disappeared following the surgery, and the iliopectineal bursa was no longer enlarged. MTX and tacrolimus were postoperatively administered to strictly control the RA. The RA was subsequently well controlled, without any increases in the levels of inflammatory markers, such as C-reactive protein and matrix metalloproteinase-3. This case demonstrated that iliopectineal bursitis was resolved following THA, without complete excision of the intrapelvic bursa, and that strict RA control led to a good clinical course without recurrent inflammation of the bursa. Similar procedures may be beneficial in other patients contraindicated for resection of the entire bursa.

摘要

本研究描述了一例因髂耻滑囊炎伴类风湿关节炎(RA)导致的腿部淋巴水肿病例,该病例通过手术以及甲氨蝶呤(MTX)和他克莫司联合治疗得到了满意控制。一名68岁男性,有6年RA病史,出现与髋关节破坏相关的髂耻滑囊炎。肿块大小逐渐增大,其右下肢出现肿胀。随后,患者因右髋部疼痛加剧和腿部水肿而住院。无色透明淋巴液从其腿部渗出,由此诊断为腿部淋巴水肿。该患者还有20年骨髓增生异常综合征病史。因此,广泛或完全切除滑囊被认为创伤性过大,故经前路进行了部分滑囊切除术。在部分滑囊切除术后,采用Hardinge入路进行了全髋关节置换术(THA)。术后腿部淋巴水肿消失,髂耻滑囊不再增大。术后给予MTX和他克莫司以严格控制RA。随后RA得到良好控制,炎症标志物如C反应蛋白和基质金属蛋白酶-3水平未出现任何升高。该病例表明,在未完全切除盆腔内滑囊的情况下,THA后髂耻滑囊炎得到缓解,并且严格控制RA导致了良好的临床病程,滑囊未出现反复炎症。类似的手术方法可能对其他禁忌进行整个滑囊切除的患者有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/3797314/7ec852798ad1/ETM-06-04-0887-g00.jpg

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