Botana L M, Espinosa J, Eleno N, Segura C, Fernández-Otero P
Agents Actions. 1985 Jul;16(5):342-5. doi: 10.1007/BF01982870.
The actions of the polyamines compound 48/80, poly-l-lysine and polymyxin B on rat pleural and peritoneal mast cell secretion have been studied. Unpurified pleural mast cells released more histamine than peritoneal mast cells when stimulated by submaximal concentrations of compound 48/80 and poly-l-lysine, but the same profile of response was observed with polymyxin B in both populations. Dose-response studies of peritoneal and pleural mast cells purified with Percoll and Ficoll and stimulated by polymyxin B showed a decreased sensitivity and decreased maximum response of peritoneal cells when Percoll was used. The maximal response of pleural cells and the sensitivity of peritoneal cells were affected only slightly by Ficoll.
已对多胺化合物48/80、聚-L-赖氨酸和多粘菌素B对大鼠胸膜和腹膜肥大细胞分泌的作用进行了研究。当用次最大浓度的化合物48/80和聚-L-赖氨酸刺激时，未纯化的胸膜肥大细胞比腹膜肥大细胞释放更多的组胺，但在两个细胞群体中，多粘菌素B刺激时观察到相同的反应模式。用Percoll和Ficoll纯化并用多粘菌素B刺激的腹膜和胸膜肥大细胞的剂量反应研究表明，当使用Percoll时，腹膜细胞的敏感性降低，最大反应降低。Ficoll对胸膜细胞的最大反应和腹膜细胞的敏感性影响较小。
