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[圆锥角膜中的角膜基质环片]

[Intacsintracorneal ring segments in keratoconus].

作者信息

El-Husseiny M, Tsintarakis T, Eppig T, Langenbucher A, Seitz B

机构信息

Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, UKS, Homburg/Saar.

出版信息

Ophthalmologe. 2013 Sep;110(9):823-6, 828-9. doi: 10.1007/s00347-013-2821-2.

Abstract

INTRODUCTION

The spectrum of stage-related therapy of keratoconus has been broadened through surgical implantation of intracorneal ring segments (INTACS) as a possible method of reducing irregular astigmatism, leading to a reduction of corneal grafts especially in young, working-aged patients with keratoconus. The purpose of the present study was to evaluate the preoperative and postoperative results of femtosecond laser-assisted implantation of INTACS in ectatic corneal diseases.

PATIENTS AND METHODS

From August 2011 to January 2013, 20 eyes from 16 patients with a clear cornea in the visual axis suffering from hard contact lens intolerance underwent surgery in the Homburg/Saar Keratoconus Center (HKC) by the same surgeon (MEH). Among these were 16 keratoconus eyes, 1 eye with pellucid marginal degeneration und 3 eyes with post-LASIK iatrogenic keratectasia. The insertion of the INTACS ring segments was achieved by a femtosecond laser-assisted procedure that created a precise 360° tunnel at a depth of 80% of the corneal thickness (395.8 ± 38.5 μm) in the 6–7 mm zone.Results. At 6 months follow-up mean uncorrected distance visual acuity improved from 0.07 ± 0.07 preoperatively to 0.6 ± 0.26 postoperatively. Mean best-corrected distance visual acuity changed from 0.4 ± 0.15 preoperatively to 0.9 ± 0.29 postoperatively. Mean sphere decreased from −7.6 ± 6.1 dpt to −1.4 ± 2.8 dpt. Astigmatism decreased from −6.0 ± 2.8 dpt preoperatively to −4.3 ± 2.0 dpt postoperatively. There was also a reduction in the mean flat K from 47.8 ± 4.7 dpt preoperatively to 44.2 ± 5.0 dpt postoperatively and in mean steep K from 51.9 ± 5.0 dpt to 48.4 ± 6.6 dpt. The central eccentricity index in the Pentacam was reduced to around 50%. Neither intraoperative nor postoperative complications (including non-responders) were observed.

CONCLUSIONS

The femtosecond laser-assisted INTACS implantation provides a valid alternative to early keratoplasty for keratoconus patients with a clear central cornea and contact lens intolerance. It is a minimally invasive and reliable method for stage-related surgical management of keratoconus.

摘要

引言

通过植入角膜基质环片(INTACS)进行手术,圆锥角膜分期相关治疗的范围得到了扩展,这是一种减少不规则散光的可行方法,尤其能减少年轻、工作年龄段圆锥角膜患者的角膜移植需求。本研究的目的是评估飞秒激光辅助植入INTACS治疗扩张性角膜疾病的术前和术后结果。

患者与方法

2011年8月至2013年1月,16例视轴区角膜透明、硬性接触镜不耐受的患者的20只眼,在洪堡/萨尔圆锥角膜中心(HKC)由同一位外科医生(MEH)进行手术。其中有16只圆锥角膜眼,1只周边透明性角膜变性眼和3只准分子激光原位角膜磨镶术(LASIK)后医源性角膜扩张眼。INTACS环片的植入通过飞秒激光辅助程序完成,该程序在6 - 7毫米区域角膜厚度80%(395.8±38.5微米)深度处创建一个精确的360°隧道。

结果

在6个月随访时,平均未矫正远视力从术前的0.07±0.07提高到术后的0.6±0.26。平均最佳矫正远视力从术前的0.4±0.15变为术后的0.9±0.29。平均球镜度数从−7.6±6.1屈光度降至−1.4±2.8屈光度。散光从术前的−6.0±2.8屈光度降至术后的−4.3±2.0屈光度。术前平均平坦角膜曲率从47.8±4.7屈光度降至术后的44.2±5.0屈光度,平均陡峭角膜曲率从51.9±5.0屈光度降至48.4±6.6屈光度。眼前节分析系统(Pentacam)中的中央偏心率指数降至约50%。未观察到术中及术后并发症(包括无反应者)。

结论

飞秒激光辅助植入INTACS为中央角膜透明且接触镜不耐受的圆锥角膜患者提供了一种有效的早期角膜移植替代方法。它是圆锥角膜分期相关手术治疗的一种微创且可靠的方法。

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