Matar C, Daas L, Suffo S, Langenbucher A, Seitz B, Eppig T
Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes UKS, Kirrberger Str. 100, 66421, Homburg/Saar, Deutschland.
Institut für Experimentelle Ophthalmologie, Universität des Saarlandes, 66421, Homburg/Saar, Deutschland.
Ophthalmologe. 2020 Nov;117(11):1092-1099. doi: 10.1007/s00347-020-01074-w.
Intracorneal ring segments (ICRS) are believed to stop the progression of keratoconus (KC). This statement on progression, however, requires knowledge about measurement reproducibility. The purpose of this study was to compare the reproducibility of tomographic parameters in eyes with KC after femtosecond laser-assisted implantation of INTACS (fs-INTACS) using two different devices and to determine which is more reliable for the follow-up of these patients.
In this study 19 KC eyes were included and repeatedly examined 5 times with the Scheimpflug topography Pentacam HR and the Casia 2 optical coherence tomography (VA-OCT) devices. Outcome measures included the reproducibility and comparability of measurements between the two devices of (1) keratometric refractive power of the anterior cornea and (2) posterior cornea, (3) maximum keratometric refractive power, (4) central corneal thickness and (5) corneal thickness at the thinnest site.
The mean differences (Pentacam minus Casia 2) of (1), (2), (3), (4) and (5) were 0.67 dpt, 0.41 dpt, 3.4 dpt, 1.5 µm and 11.8 µm, respectively. The mean SDs of the 5 repeat measurements for (1), (2), (3), (4) and (5) were 0.20 dpt/0.20 dpt, 0.10 dpt/0.07 dpt, 0.75 dpt/0.5 dpt, 6.5 µm/2.4 µm (p = 0.007) and 7.3 µm/1.9 µm (p = 0.001) for Pentacam and Casia 2, respectively. Cronbach's alpha was better than 0.98 for both devices and all parameters.
Both Casia 2 and Pentacam enable a reliable assessment of the corneal refractive power in KC after fs-INTACS implantation; however, the reproducibility was significantly better with Casia 2 only for the measurement of corneal thickness. The Pentacam showed significantly higher values for the mean anterior and posterior corneal refractive power and measured significantly thicker at the thinnest point of the cornea compared to Casia 2.
角膜内环片(ICRS)被认为可阻止圆锥角膜(KC)的进展。然而,关于进展情况的这一说法需要了解测量的可重复性。本研究的目的是比较使用两种不同设备在飞秒激光辅助植入INTACS(fs - INTACS)后圆锥角膜患者眼中断层扫描参数的可重复性,并确定哪种设备对于这些患者的随访更可靠。
本研究纳入了19只圆锥角膜眼,使用眼前节分析系统Pentacam HR和Casia 2光学相干断层扫描(VA - OCT)设备对其进行5次重复检查。观察指标包括两种设备之间以下测量的可重复性和可比性:(1)前角膜的角膜屈光力;(2)后角膜的角膜屈光力;(3)最大角膜屈光力;(4)中央角膜厚度;(5)最薄处的角膜厚度。
(1)、(2)、(3)、(4)和(5)的平均差值(Pentacam减去Casia 2)分别为0.67屈光度、0.41屈光度、3.4屈光度、1.5微米和11.8微米。Pentacam和Casia 2对(1)、(2)、(3)、(4)和(5)的5次重复测量的平均标准差分别为0.20屈光度/0.20屈光度、0.10屈光度/0.07屈光度、0.75屈光度/0.5屈光度、6.5微米/2.4微米(p = 0.007)和7.3微米/1.9微米(p = 0.001)。两种设备和所有参数的Cronbach's α均优于0.98。
Casia 2和Pentacam均可对fs - INTACS植入术后圆锥角膜的角膜屈光力进行可靠评估;然而,仅在角膜厚度测量方面,Casia 2的可重复性明显更好。与Casia 2相比,Pentacam显示前、后角膜平均屈光力值显著更高,且在角膜最薄点处测量的厚度显著更厚。