Geibel Sebastian, Waksman Gabriel
Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London, WC1E7HX, UK.
Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London, WC1E7HX, UK.
Biochim Biophys Acta. 2014 Aug;1843(8):1559-67. doi: 10.1016/j.bbamcr.2013.09.023. Epub 2013 Oct 16.
Secretion systems are specialized in transport of proteins, DNA or nutrients across the cell envelope of bacteria and enable them to communicate with their environment. The chaperone-usher (CU) pathway is used for assembly and secretion of a large family of long adhesive protein polymers, termed pili, and is widespread among Gram-negative pathogens [1]. Moreover, recent evidence has indicated that CU secretion systems are also involved in sporulation [2,3]. In this review we focus on the structural biology of the paradigmatic type 1 and P pili CU systems encoded by uropathogenic Escherichia coli (UPEC), where recent progress has provided unprecedented insights into pilus assembly and secretion mechanism. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.
分泌系统专门负责将蛋白质、DNA或营养物质运输穿过细菌的细胞包膜，使细菌能够与周围环境进行交流。伴侣-外膜蛋白途径用于组装和分泌一大类称为菌毛的长粘附蛋白聚合物，在革兰氏阴性病原体中广泛存在[1]。此外，最近的证据表明，伴侣-外膜蛋白分泌系统也参与芽孢形成[2,3]。在本综述中，我们重点关注由致病性大肠杆菌（UPEC）编码的典型1型菌毛和P菌毛伴侣-外膜蛋白系统的结构生物学，近期的进展为菌毛组装和分泌机制提供了前所未有的见解。本文是名为：细菌中的蛋白质运输和分泌的特刊的一部分。客座编辑：阿纳斯塔西奥斯·埃康诺莫和罗斯·达尔贝。
