Sagata N, Yasunaga T, Ikawa Y
FEBS Lett. 1985 Nov 11;192(1):37-42. doi: 10.1016/0014-5793(85)80038-7.
Human T-cell leukemia and bovine leukemia viruses have a potential transforming gene, termed X. In addition to the major open reading frame known to encode a functional protein, the X gene harbors another short open reading frame which overlaps this major one. Both of these open reading frames are found on a single spliced X mRNA in a potentially functional form. Circumstantial evidence strongly suggests that they are both translated from the single X mRNA molecule, showing striking similarity to the translation mechanism of an adenovirus Elb gene mRNA. We note that the short open reading frame has the capability to encode a putative nuclear protein with structural features similar to those of an AIDS virus trans-acting protein.
人类T细胞白血病病毒和牛白血病病毒都有一个潜在的转化基因，称为X基因。除了已知编码功能性蛋白质的主要开放阅读框外，X基因还含有另一个与该主要开放阅读框重叠的短开放阅读框。这两个开放阅读框都以潜在的功能形式存在于单个剪接的X mRNA上。间接证据有力地表明，它们都从单个X mRNA分子翻译而来，这与腺病毒E1b基因mRNA的翻译机制有着惊人的相似性。我们注意到，这个短开放阅读框能够编码一种假定的核蛋白，其结构特征与艾滋病病毒反式作用蛋白相似。
