Michels Fernanda Alessandra Silva, Latorre Maria do Rosario Dias de Oliveira, Maciel Maria do Socorro
University of São Paulo, School of Public Health, Cancer Registry of São Paulo, SP, Brazil.
Rev Bras Epidemiol. 2013 Jun;16(2):352-63. doi: 10.1590/S1415-790X2013000200011.
To validate and assess reliability and understanding of the EORTC-C30 quality of life questionnaire and its breast cancer specific module, the EORTC-BR23.
This study was conducted at the AC Camargo Cancer Hospital, São Paulo, Brazil. A total of 100 women diagnosed with breast cancer were interviewed. Internal consistency, confirmatory factorial analysis, convergent validity, construct validity and degree of understanding were examined. Reliability was assessed by comparison of means at times 1 and 2, inter-class coefficient and Bland-Altman graphics.
Cronbach's alpha ranged from 0.72 to 0.86 for the EORTC-C30 and from 0.78 to 0.83 for the EORTC-BR23 questionnaire. Most questions were confirmed in the confirmatory factorial analysis. In the construct validity analysis, the questionnaires were capable of differentiating patients with or without lymphedema, apart from the symptom scales of both questionnaires. Both questionnaires presented a significant correlation in most domains of the SF-36, in the convergent validity analysis. Only a few criticisms were reported concerning questions, and the mean grade of understanding was high (C30 = 4.91 and BR23 = 4.89). The questionnaires presented good rates of reliability, with the exception of the functional scale of the C30 and the symptom scale of the BR23.
The EORTC-C30 and EORTC-BR23 quality of life questionnaires were validated, presented good rates of reliability and are easily understood, allowing them to be used in Brazil to assess quality of life among women with breast cancer.
验证并评估欧洲癌症研究与治疗组织生活质量问卷C30（EORTC-C30）及其乳腺癌特异性模块欧洲癌症研究与治疗组织乳腺癌问卷23（EORTC-BR23）的可靠性及易懂性。
本研究在巴西圣保罗的AC卡马戈癌症医院开展。共对100名确诊为乳腺癌的女性进行了访谈。检查了内部一致性、验证性因子分析、收敛效度、结构效度和理解程度。通过比较第1次和第2次测量的均值、组内相关系数和布兰德-奥特曼图评估可靠性。
EORTC-C30问卷的Cronbach's α系数范围为0.72至0.86，EORTC-BR23问卷的该系数范围为0.78至0.83。在验证性因子分析中，大多数问题得到确认。在结构效度分析中，除了两份问卷的症状量表外，这两份问卷能够区分有或没有淋巴水肿的患者。在收敛效度分析中，两份问卷在SF-36的大多数领域都呈现出显著相关性。关于问题仅报告了少数批评意见，理解的平均得分较高（C30 = 4.91，BR23 = 4.89）。问卷呈现出良好的可靠性，C30的功能量表和BR23的症状量表除外。
欧洲癌症研究与治疗组织生活质量问卷C30和欧洲癌症研究与治疗组织乳腺癌问卷23经过验证，具有良好的可靠性且易于理解，可在巴西用于评估乳腺癌女性的生活质量。
