卵巢常见上皮性肿瘤中淀粉酶的免疫组织化学研究

Immunohistochemical study of amylase in common epithelial tumors of the ovary.

作者信息

Ueda G, Yamasaki M, Inoue M, Tanaka Y, Abe Y, Ogawa M

出版信息

Int J Gynecol Pathol. 1985;4(3):240-4. doi: 10.1097/00004347-198509000-00008.

DOI:10.1097/00004347-198509000-00008

Abstract

Cellular localization of amylase in various ovarian tumors was studied by the immunoperoxidase method using an antibody to human pancreatic amylase. Amylase was present in eight of 34 serous carcinomas and eight of 27 endometrioid carcinomas. However, only in one poorly differentiated serous carcinoma and two well-differentiated endometrioid carcinomas were a large number of amylase-reactive cells found. Five benign and three borderline serous tumors contained no amylase. Also, amylase was not detected in any of 34 mucinous tumors or five malignant clear cell tumors. The results obtained suggest that amylase will be a useful tumor marker, when present, for follow-up of endometrioid and serous carcinomas of the ovary.

摘要

采用抗人胰腺淀粉酶抗体，通过免疫过氧化物酶法研究了淀粉酶在各种卵巢肿瘤中的细胞定位。在34例浆液性癌中有8例存在淀粉酶，在27例子宫内膜样癌中有8例存在淀粉酶。然而，仅在1例低分化浆液性癌和2例高分化子宫内膜样癌中发现大量淀粉酶反应性细胞。5例良性和3例交界性浆液性肿瘤未含淀粉酶。此外，在34例黏液性肿瘤或5例恶性透明细胞肿瘤中均未检测到淀粉酶。所得结果表明，淀粉酶若存在，将成为卵巢子宫内膜样癌和浆液性癌随访的有用肿瘤标志物。