Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California, USA.
Occup Environ Med. 2014 Mar;71(3):159-66. doi: 10.1136/oemed-2013-101653. Epub 2013 Oct 16.
An 'information gap' has been identified regarding the effects of chronic disease on occupational injury risk. We investigated the association of ischaemic heart disease, hypertension, diabetes, depression and asthma with acute occupational injury in a cohort of manufacturing workers from 1 January 1997 through 31 December 2007.
We used administrative data on real-time injury, medical claims, workplace characteristics and demographics to examine this association. We employed a piecewise exponential model within an Andersen-Gill framework with a frailty term at the employee level to account for inclusion of multiple injuries for each employee, random effects at the employee level due to correlation among jobs held by an employee, and experience on the job as a covariate.
One-third of employees had at least one of the diseases during the study period. After adjusting for potential confounders, presence of these diseases was associated with increased hazard of injury: heart disease (HR 1.23, 95% CI 1.11 to 1.36), diabetes (HR 1.17, 95% CI 1.08 to 1.27), depression (HR 1.25, 95% CI 1.12 to 1.38) and asthma (HR 1.14, 95% CI 1.02 to 1.287). Hypertension was not significantly associated with hazard of injury. Associations of chronic disease with injury risk were less evident for more serious reportable injuries; only depression and a summary health metric derived from claims remained significantly positive in this subset.
Our results suggest that chronic heart disease, diabetes and depression confer an increased risk for acute occupational injury.
据报道,慢性病对职业伤害风险的影响存在信息差距。我们调查了 1997 年 1 月 1 日至 2007 年 12 月 31 日期间制造业工人队列中缺血性心脏病、高血压、糖尿病、抑郁症和哮喘与急性职业伤害的关联。
我们使用实时伤害、医疗索赔、工作场所特征和人口统计数据的行政数据来研究这种关联。我们在 Andersen-Gill 框架内使用分段指数模型,在员工层面使用脆弱性术语来解释每个员工的多次伤害纳入情况,员工层面的随机效应归因于员工所从事工作之间的相关性,以及工作经验作为协变量。
三分之一的员工在研究期间至少患有一种疾病。在调整了潜在混杂因素后,这些疾病的存在与受伤风险增加相关:心脏病(HR 1.23,95%CI 1.11 至 1.36)、糖尿病(HR 1.17,95%CI 1.08 至 1.27)、抑郁症(HR 1.25,95%CI 1.12 至 1.38)和哮喘(HR 1.14,95%CI 1.02 至 1.287)。高血压与受伤风险无显著相关性。慢性疾病与受伤风险的关联在更严重的报告伤害中不太明显;只有抑郁症和索赔中得出的综合健康指标在这一亚组中仍然呈显著阳性。
我们的结果表明,慢性心脏病、糖尿病和抑郁症会增加急性职业伤害的风险。