Park Moo In
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Clin Endosc. 2013 Sep;46(5):450-5. doi: 10.5946/ce.2013.46.5.450. Epub 2013 Sep 30.
Foregut neuroendocrine tumors (NETs) include those arising in the esophagus, stomach, pancreas, and duodenum and seem to have a broad range of clinical behavior from benign to metastatic. Several factors including the advent of screening endoscopy may be related to increased incidence of gastrointestinal NETs; thus, many foregut NETs are diagnosed at an early stage. Early foregut NETs, such as those of the stomach and duodenum, can be managed with endoscopic treatment because of a low frequency of lymph node and distant metastases. However, controversy continues concerning the optimal management of early foregut NETs due to a lack of controlled prospective studies. Several issues such as indications, technical issues, and outcomes of endoscopic treatment for early foregut NETs are reviewed based on some published studies.
前肠神经内分泌肿瘤（NETs）包括起源于食管、胃、胰腺和十二指肠的肿瘤，其临床行为似乎具有从良性到转移性的广泛范围。包括筛查内镜检查的出现在内的几个因素可能与胃肠道NETs发病率增加有关；因此，许多前肠NETs在早期被诊断出来。早期前肠NETs，如胃和十二指肠的NETs，由于淋巴结转移和远处转移的频率较低，可以通过内镜治疗进行处理。然而，由于缺乏对照前瞻性研究，关于早期前肠NETs的最佳治疗仍存在争议。基于一些已发表的研究，对早期前肠NETs内镜治疗的适应症、技术问题和结果等几个问题进行了综述。
