Lee Jin, Oh Sung Jin
Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Case Rep Oncol. 2021 Sep 6;14(3):1271-1276. doi: 10.1159/000518078. eCollection 2021 Sep-Dec.
Gastric neuroendocrine tumors (NETs) are rare lesions that arise from enterochromaffin-like cells of the gastric mucosa. Gastric NETs are classified into 3 types of NETs and poorly differentiated neuroendocrine cancers. Most gastric NETs usually present as hemispherical, yellowish, polypoid lesions with a central depression and often as subepithelial tumors (SETs) because they are confined within the submucosal layer. Here, we report a case of gastric NET presenting as SET mimicking a gastrointestinal stromal tumor (GIST). Endoscopy revealed a 2.3-cm-sized SET with intact surface mucosa, and endoscopic ultrasonography showed a homogeneous hypoechoic lesion with a well-circumscribed margin. Typical features of gastric NET, such as yellowish mucosal changes or central ulceration, were not observed. GIST was suspected, and a laparoscopic wedge resection was performed. The final diagnosis was gastric NET with grade 2 differentiation.
胃神经内分泌肿瘤（NETs）是一种罕见的病变，起源于胃黏膜的肠嗜铬样细胞。胃NETs分为3种类型的NETs和低分化神经内分泌癌。大多数胃NETs通常表现为半球形、淡黄色、息肉样病变，中央有凹陷，且常为黏膜下肿瘤（SETs），因为它们局限于黏膜下层。在此，我们报告一例表现为SET且酷似胃肠道间质瘤（GIST）的胃NET病例。内镜检查发现一个2.3厘米大小的SET，表面黏膜完整，内镜超声显示为边界清晰的均匀低回声病变。未观察到胃NET的典型特征，如淡黄色黏膜改变或中央溃疡。怀疑为GIST，遂行腹腔镜楔形切除术。最终诊断为2级分化的胃NET。
