人类蛋白质组组织（HUPO）人类蛋白质组计划的策略、组织与进展。
The strategy, organization, and progress of the HUPO Human Proteome Project.
作者信息
Omenn Gilbert S
机构信息
Center for Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218, USA.
出版信息
J Proteomics. 2014 Apr 4;100:3-7. doi: 10.1016/j.jprot.2013.10.012. Epub 2013 Oct 19.
Abstract
UNLABELLED
The Human Proteome Project is a major, comprehensive initiative of the Human Proteome Organization. This global collaborative effort aims to identify and characterize at least one protein product and many PTM, SAP, and splice variant isoforms from the 20,300 human protein-coding genes. The deliverables are an extensive parts list and an array of technology platforms, reagents, spectral libraries, and linked knowledge bases that advance the field and facilitate the use of proteomics by a much wider community of life scientists. Such enablement will help address the Grand Challenge of using proteomics to bridge major gaps between evidence of genomic variation and diverse phenotypes.
BIOLOGICAL SIGNIFICANCE
The HUPO Human Proteome Project (HPP) has made an outstanding launch, including a special issue of the Journal of Proteome Research on the Chromosome-centric HPP with a total of 48 articles. This article is part of a Special Issue: Can Proteomics Fill the Gap Between Genomics and Phenotypes?
摘要
未标注
人类蛋白质组计划是人类蛋白质组组织的一项重大综合性倡议。这项全球合作努力旨在从20300个人类蛋白质编码基因中鉴定并表征至少一种蛋白质产物以及许多翻译后修饰、序列变异体和剪接变体亚型。其成果包括一份详尽的部件清单以及一系列技术平台、试剂、光谱库和相关知识库，这些推动了该领域的发展，并便于更广泛的生命科学家群体使用蛋白质组学。这种赋能将有助于应对利用蛋白质组学弥合基因组变异证据与多样表型之间重大差距这一重大挑战。
生物学意义
人类蛋白质组组织的人类蛋白质组计划（HPP）有了出色的开局，包括《蛋白质组研究杂志》以染色体为中心的HPP特刊，共48篇文章。本文是“蛋白质组学能否填补基因组学与表型之间的空白？”特刊的一部分。
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