Department of Ophthalmology, Columbia University Medical Center, Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY.
J Glaucoma. 2014 Jan;23(1):e1-5. doi: 10.1097/IJG.0000000000000006.
The aim of this study was to quantitatively study the retinal nerve fiber layer (RNFL) thickness in children born prematurely with isolated optic nerve cupping.
Six otherwise healthy premature children with clinical evidence of increased cup to disc ratios were enrolled in this observational case series. RNFL thickness was measured using Cirrus optical coherence tomography (OCT) optic disc cube 200×200 protocol and compared with age-matched normal controls using T test for statistical significance, with Bonferroni correction when appropriate.
Nerve fiber layer measurements showed a statistically significant decrease in overall RNFL. Superior quadrant RNFL thinning was statistically significant and inferior, nasal, and temporal nerve fiber layer thickness was decreased, although results were not statistically significant.
Nerve fiber layer thinning in children born prematurely showing enlarged cup to disc ratios appears more consistent with optic nerve hypoplasia than glaucoma, as reflected by the markedly decreased average nerve fiber layer thickness with no other hallmarks of congenital glaucoma.
本研究旨在定量研究孤立性视神经杯盘比增大的早产儿的视网膜神经纤维层（RNFL）厚度。
本观察性病例系列纳入了 6 名其他方面均健康的早产儿，这些早产儿有临床证据表明杯盘比增加。使用 Cirrus 光学相干断层扫描（OCT）视神经盘立方 200×200 方案测量 RNFL 厚度，并使用 T 检验比较年龄匹配的正常对照组，当适用时使用 Bonferroni 校正进行统计显著性检验。
神经纤维层测量显示总体 RNFL 有统计学意义的减少。上方象限 RNFL 变薄具有统计学意义，下方、鼻侧和颞侧神经纤维层厚度减少，尽管结果无统计学意义。
显示杯盘比增大的早产儿的神经纤维层变薄似乎更符合视神经发育不良而不是青光眼，这反映在明显减少的平均神经纤维层厚度，没有其他先天性青光眼的特征。
