Department of Endocrinology and MetabolismHacettepe University School of Medicine, 06100 Sihhiye, Ankara, Turkey.
Endocr Connect. 2013 Oct 24;2(4):R30-8. doi: 10.1530/EC-13-0061. Print 2013.
Adipose tissue secretes a variety of active biological substances, called adipocytokines, that act in an autocrine, paracrine, and endocrine manner. They have roles in appetite control, thermogenesis, and thyroid and reproductive functions. All these molecules may lead to local and generalized inflammation, mediating obesity-associated vascular disorders including hypertension, diabetes, atherosclerosis, and insulin resistance. Thyroid dysfunction is associated with changes in body weight, thermogenesis, and energy expenditure. The connections between cardiovascular risk factors such as dyslipidemia, impaired glucose tolerance, insulin resistance, atherosclerosis, and thyroid dysfunction have been reported in several studies. The adipocytokines serve as causative or protective factors in the development of these disorders in the states of thyroid dysfunction. Abnormal levels of adipocytokines (adiponectin (ADP), leptin, resistin, vaspin, and visfatin) in hypo- and hyperthyroidism have been reported with controversial results. This review aims to update the implication of novel adipokines ADP, vaspin, and visfatin in thyroid dysfunction.
脂肪组织分泌多种具有活性的生物物质,称为脂肪细胞因子,以自分泌、旁分泌和内分泌的方式发挥作用。它们在食欲控制、产热、甲状腺和生殖功能中发挥作用。所有这些分子都可能导致局部和全身性炎症,介导与肥胖相关的血管疾病,包括高血压、糖尿病、动脉粥样硬化和胰岛素抵抗。甲状腺功能障碍与体重、产热和能量消耗的变化有关。几项研究报道了心血管危险因素(血脂异常、葡萄糖耐量受损、胰岛素抵抗、动脉粥样硬化和甲状腺功能障碍)之间的联系。在甲状腺功能障碍状态下,脂肪细胞因子是这些疾病发展的因果或保护因素。已经报道了在甲状腺功能减退症和甲状腺功能亢进症中脂肪细胞因子(脂联素(ADP)、瘦素、抵抗素、vaspin 和 visfatin)的异常水平,但结果存在争议。这篇综述旨在更新新型脂肪细胞因子 ADP、vaspin 和 visfatin 在甲状腺功能障碍中的作用。