Zygmunt Małgorzata, Dudek Magdalena, Bilska-Wilkosz Anna, Bednarski Marek, Mogilski Szczepan, Knutelska Joanna, Sapa Jacek
Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Kraków, Poland.
Acta Pol Pharm. 2013 Sep-Oct;70(5):899-904.
This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S*) level, infiltration of neutrophils and vascular permeability in a model of zymosan-induced peritonitis. The study showed that lipoic acid increased the sulfane sulfur level. Also, it decreased count of neutrophils and inhibition of intensity of early vascular permeability compared to the control group. These studies indicated that LA exhibits antiinflammatory activity. LA serves as a sulfane sulfur acceptor and releases sulfane sulfur in the form of hydrogen sulfide (H2S), which is probably responsible for its anti-inflammatory activity.
本研究旨在探讨硫辛酸（LA）对酵母聚糖诱导的腹膜炎模型中次磺酸硫（S*）水平、中性粒细胞浸润及血管通透性的影响。研究表明，硫辛酸可提高次磺酸硫水平。此外，与对照组相比，它还可减少中性粒细胞数量，并抑制早期血管通透性的增强。这些研究表明，硫辛酸具有抗炎活性。硫辛酸作为次磺酸硫受体，以硫化氢（H2S）的形式释放次磺酸硫，这可能是其抗炎活性的原因。
