Dudek Magdalena, Razny Katarzyna, Bilska-Wilkosz Anna, Iciek Malgorzata, Sapa Jacek, Wlodek Lidia, Filipek Barbara
Department of Pharmacodynamids, Jagiellonian University, Collegium Medicum; Kraków-Poland.
Anatol J Cardiol. 2016 May;16(5):306-9. doi: 10.5152/AnatolJCardiol.2015.6217. Epub 2015 Jun 30.
The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration. Alpha-lipoic acid is a drug used in diabetic neuropathy, often in obese patients, to treat hypertension. Therefore, knowledge of the potential antihypertensive effect of alpha-lipoic acid even after a single dose and possibly too much pressure reduction is interesting and useful.
The mechanism of the hypotensive effect of alpha-lipoic acid was examined in normotensive rats in vivo after a single intraperitoneal administration, blood pressure in the left carotid artery of the rats was measured prior to the administration of the compounds (alpha- lipoic acid and/or glibenclamide) and 80 min thereafter.
Alpha-lipoic acid at a dosage of 50 mg/kg b.w. i.p. significantly decreased the blood pressure from the 50th min after drug administration. This cardiovascular effect of this compound was reversed by glibenclamide, a selective KATP blocker. Glibenclamide alone at this dose did not significantly affect the blood pressure. Statistical significance was evaluated using two-way ANOVA.
This suggests that alpha-lipoic acid affects ATP-dependent potassium channels. It is possible that this is an indirect effect of hydrogen sulfide because alpha-lipoic acid can increase its concentration. The results obtained in this study are very important because the patients taking alpha-lipoic acid may be treated for co-existing hypertension. Therefore, the possibility of blood pressure lowering by alpha-lipoic acid should be taken into account, although it does not lead to excessive orthostatic hypotension.
在慢性研究中已多次探究α-硫辛酸对血压的影响，但尚无关于单次给药后该化合物作用效果的研究。α-硫辛酸是一种用于治疗糖尿病性神经病变的药物，常用于肥胖患者，也可用于治疗高血压。因此，了解α-硫辛酸即使单次给药后的潜在降压作用以及可能出现的过度降压情况，既有趣又有用。
在正常血压大鼠体内单次腹腔注射后，研究α-硫辛酸降压作用的机制。在给予化合物（α-硫辛酸和/或格列本脲）之前及之后80分钟，测量大鼠左颈动脉血压。
腹腔注射剂量为50mg/kg体重的α-硫辛酸，在给药后第50分钟开始显著降低血压。该化合物的这种心血管效应被选择性KATP阻滞剂格列本脲逆转。此剂量的格列本脲单独使用时对血压无显著影响。采用双向方差分析评估统计学意义。
这表明α-硫辛酸影响ATP依赖性钾通道。这可能是硫化氢的间接作用，因为α-硫辛酸可增加其浓度。本研究所得结果非常重要，因为服用α-硫辛酸的患者可能同时患有高血压。因此，应考虑α-硫辛酸降低血压的可能性，尽管它不会导致过度体位性低血压。
