Health Outcomes Practice, Kantar Health, 11 Madison Avenue, 12th Floor, New York, NY 10010, USA.
Health Qual Life Outcomes. 2013 Oct 22;11:175. doi: 10.1186/1477-7525-11-175.
The aim of the current study was to quantify the burden of peripheral arterial disease (PAD) with respect to health-related quality of life, work productivity and activity impairment, and healthcare resource utilization.
Data were obtained from the 2010 EU National Health and Wellness Survey (NHWS), which included participants from France, Germany, Italy, Spain, and the UK (5 EU, N = 57,805) as well as the 2010 US NHWS (N = 75,000). The NHWS is an annual, cross-sectional, self-administered Internet survey which employs a stratified random sampling frame to match the age and gender characteristics of the NHWS sample with known population statistics. Participants who self-reported a diagnosis of PAD were compared with participants who did not self-report a diagnosis of PAD on health-related quality of life (mental and physical component summary scores and health utilities from the Short Form-12v2), work productivity and activity impairment (Work Productivity and Activity Impairment questionnaire), and healthcare resource use in terms of the number of physician visits, emergency room visits, and hospitalizations in the past six months through regression modeling adjusting for demographics and health characteristics.
A total of 743 (1.29%) and 777 (1.04%) participants self-reported a diagnosis of PAD in the 5 EU and US, respectively. After adjusting for demographics and health characteristics, patients with PAD reported worse health-related quality of life, as measured by health utilities (5 EU: 0.66 vs. 0.70; US: 0.66 vs. 0.72; all p < .05), greater overall work impairment percentage (5 EU: 38.27% vs. 27.48%; US: 23.89% vs. 14.26%) and greater healthcare resource use compared to participants without PAD (all p < .05).
These results suggest a significant burden for patients with PAD in both the 5 EU countries and the US with respect to both quality of life and economic outcomes. Improved management of these patients may have profound effects from both patient and societal perspectives.
本研究旨在评估外周动脉疾病（PAD）对健康相关生活质量、工作生产力和活动能力受损以及医疗资源利用的负担。
数据来自 2010 年欧盟国家健康与健康调查（NHWS），该调查包括来自法国、德国、意大利、西班牙和英国的参与者（5 个欧盟国家，N=57805）和 2010 年美国 NHWS（N=75000）。NHWS 是一项年度、横断面、自我管理的互联网调查，采用分层随机抽样框架，使 NHWS 样本的年龄和性别特征与已知的人口统计数据相匹配。自我报告患有 PAD 的参与者与未自我报告患有 PAD 的参与者在健康相关生活质量（短格式 12v2 的心理和生理成分综合评分和健康效用）、工作生产力和活动能力受损（工作生产力和活动能力受损问卷）以及过去六个月内的医疗资源使用（医生就诊次数、急诊就诊次数和住院次数）方面进行比较，通过回归模型进行调整，考虑人口统计学和健康特征。
共有 743 名（1.29%）和 777 名（1.04%）参与者在 5 个欧盟国家和美国分别自我报告患有 PAD。在调整人口统计学和健康特征后，患有 PAD 的患者报告的健康相关生活质量更差，表现为健康效用（5 个欧盟：0.66 比 0.70；美国：0.66 比 0.72；均 P<.05）、总体工作受损百分比（5 个欧盟：38.27%比 27.48%；美国：23.89%比 14.26%）和医疗资源利用率更高，与无 PAD 的参与者相比（均 P<.05）。
这些结果表明，在 5 个欧盟国家和美国，PAD 患者在生活质量和经济结果方面都面临着巨大的负担。从患者和社会的角度来看，改善这些患者的管理可能会产生深远的影响。
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