Bosemani Thangamadhan, Anghelescu Cristina, Boltshauser Eugen, Hoon Alexander H, Pearl Phillip L, Craiu Dana, Johnston Michael V, Huisman Thierry A G M, Poretti Andrea
Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pediatric Neurology Clinic, Alexandru Obregia Hospital, Bucharest, Romania.
Eur J Paediatr Neurol. 2014 May;18(3):249-56. doi: 10.1016/j.ejpn.2013.09.010. Epub 2013 Oct 9.
A neuroimaging-based pattern-recognition approach has been shown to be very helpful in the diagnosis of a wide range of pediatric central nervous system diseases. Few disorders may selectively affect the subthalamic nucleus in children including Leigh syndrome, succinic semialdehyde dehydrogenase deficiency, kernicterus, chronic end-stage liver failure and near total hypoxic-ischemic injury in the full-term neonates. The consideration of the constellation of clinical history and findings as well as additional neuroimaging findings should allow planning the appropriate diagnostic tests to make the correct diagnosis in children with involvement of the subthalamic nucleus.
一种基于神经影像学的模式识别方法已被证明在诊断多种小儿中枢神经系统疾病方面非常有帮助。很少有疾病会选择性地影响儿童的丘脑底核，包括 Leigh 综合征、琥珀酸半醛脱氢酶缺乏症、核黄疸、慢性终末期肝衰竭以及足月儿近乎完全的缺氧缺血性损伤。综合考虑临床病史、体征以及其他神经影像学表现，应有助于规划适当的诊断测试，以便对累及丘脑底核的儿童做出正确诊断。
