Section of Sports Medicine.
J Sports Sci Med. 2012 Jun 1;11(2):238-44. eCollection 2012.
Bone-tendon junction (BTJ) overuse injuries are common athletic and occupational problems. BTJ injuries may sometimes be caused by resuming training too early after injury. To study the effects of post-injury resuming training within 48 hours on the acute injury healing process, as it is often the case for athletes. Twelve mature female rabbits were assigned to one of the following groups: acute injury (AI, n = 6), post-injury early return to training (PIERT, n = 6) and normal control (CON, n = 6). Tissue specimens were harvested at week 4. The radiological and histological characteristics of the AI and PIERT groups were compared among the groups. The trabecular thickness of the PIERT group was significantly different from those of the AI and CON group. A histological evaluation revealed poor collagen fibre alignment, extensive scar tissue and lowered cell density in the AI and PIERT groups compared with the CON group, but no significant differences were observed between the AI group and the PIERT group. The fibrocartilage zone and proteoglycan area in the PIERT group were significantly different from those in AI group. No differences were observed in the Total VOI volume (TV), Object volume (OBV), Percent object volume (BV/TV) and trabecular number (Tb.N) among the AI, PIERT and CON groups. In conclusion, a repeatable animal model of bone-tendon junction acute micro-damage by puncture was established. Resuming training in 48 hours did not significantly deteriorate the BTJ injury healing, but improved bone remodelling and increased fibrocartilage zone thickness. Key pointsAn easy and repeatable bone-tendon junction injury model was established in this study, it will provide a platform to the injury research.Post-injury resuming training in 48 hours did not delay the acute bone-tendon junction injury healing process, it provided a basic theory for the post-injury training.To find the proper post-injury training intensity will help athletes to train scientifically, it is the destination of our next research.
骨-腱结合部（BTJ）过度使用损伤是常见的运动和职业性问题。BTJ 损伤有时可能是由于受伤后过早恢复训练引起的。为了研究受伤后 48 小时内恢复训练对急性损伤愈合过程的影响，就像运动员经常发生的那样。将 12 只成熟雌性兔子分为以下三组：急性损伤（AI，n=6）、受伤后早期返回训练（PIERT，n=6）和正常对照（CON，n=6）。在第 4 周采集组织标本。比较 AI 和 PIERT 组之间的影像学和组织学特征。PIERT 组的小梁厚度与 AI 和 CON 组有显著差异。组织学评价显示，与 CON 组相比，AI 和 PIERT 组的胶原纤维排列不良，广泛的瘢痕组织和细胞密度降低，但 AI 组和 PIERT 组之间无显著差异。PIERT 组的纤维软骨带和糖胺聚糖区与 AI 组有显著差异。在 AI、PIERT 和 CON 组之间，总 VOI 体积（TV）、目标体积（OBV）、目标体积百分比（BV/TV）和小梁数（Tb.N）无差异。结论：建立了一种可重复的穿刺性 BTJ 急性微损伤动物模型。48 小时内恢复训练不会显著加重 BTJ 损伤愈合，但改善了骨重塑和增加了纤维软骨带厚度。关键点本研究建立了一种简单、可重复的 BTJ 损伤模型，为损伤研究提供了一个平台。48 小时内受伤后恢复训练不会延迟急性 BTJ 损伤愈合过程，为受伤后训练提供了一个基本理论。找到适当的受伤后训练强度将有助于运动员进行科学训练，这是我们下一步研究的目标。
