Heider H, Markushin S, Schroeder C, Ghendon Y
Arch Virol. 1985;86(3-4):283-90. doi: 10.1007/BF01309832.
The action of the anticholinergic drug Norakin (triperiden) on the reproduction of influenza virus A and B strains was studied. In cell culture, primary transcription of influenza A/FPV/Weybridge and of influenza B/Japan/73 is strongly inhibited by Norakin (20 micrograms/ml). When present simultaneously, Norakin and rimantadine exert an additive effect. Rimantadine-resistant mutants of influenza A exhibit a definite, though limited, cross-resistance to Norakin, and vice versa. The results indicate that Norakin blocks early stages of the infectious cycle and that the modes of antiviral action of Norakin and rimantadine are not identical.
研究了抗胆碱能药物诺拉金（曲哌立登）对甲型和乙型流感病毒株繁殖的作用。在细胞培养中，诺拉金（20微克/毫升）强烈抑制甲型流感病毒A/FPV/韦布里奇株和乙型流感病毒B/日本/73株的初级转录。当同时存在时，诺拉金和金刚烷胺发挥相加作用。甲型流感病毒的金刚烷胺抗性突变株对诺拉金表现出一定程度的、虽有限但明确的交叉抗性，反之亦然。结果表明，诺拉金阻断感染周期的早期阶段，且诺拉金和金刚烷胺的抗病毒作用模式不同。
