与流感病毒对诺拉金耐药性相关的血凝素基因突变。
Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin.
作者信息
Prösch S, Heider H, Schroeder C, Krüger D H
机构信息
Institute of Medical Virology, Humboldt University, Berlin, German Democratic Republic.
出版信息
Arch Virol. 1988;102(1-2):125-9. doi: 10.1007/BF01315569.
PMID:3196166
Abstract
The nucleotide sequences of the hemagglutinin genes of four norakin-resistant mutants of Influenza A/FPV/Weybridge were determined and compared to the wild-type hemagglutinin. All mutants show one or two amino acid substitutions which are discussed to destabilise the pH 7 conformation of hemagglutinin.
摘要
测定了甲型流感病毒/FPV/韦布里奇株的四个对诺拉金耐药突变体的血凝素基因的核苷酸序列，并与野生型血凝素进行了比较。所有突变体均显示出一到两个氨基酸取代，据讨论这些取代会破坏血凝素在pH 7时的构象稳定性。
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